Abstract
Purpose: :
A recent study identified single nucleotide polymorphisms (SNP) within the IL1 gene cluster at chromosomal locus 2q13 that were associated with risk for primary open angle glaucoma (POAG) in Caucasians. The aim of this study was to investigate the association between these IL1 SNPs and susceptibility to POAG in Chinese patients, with both high tension glaucoma (HTG) and normal tension glaucoma (NTG).
Methods: :
Genotypes were determined by polymerase chain reaction (PCR) and restriction digest enzymes at the following loci: IL1A (–889C/T), IL1B (+3953C/T), and IL1B (–511C/T). The association of individual SNPs with glaucoma was evaluated using chi–square test and logistic regression.
Results: :
A total of 211 POAG (consisting of 94 NTG and117 HTG) and 83 normal control Chinese subjects were studied. There was no significant difference in allele frequencies for POAG compared with controls. There was also no difference found between NTG and HTG.
Conclusions: :
This study did not find an association between IL1 gene cluster polymorphisms and POAG in Chinese glaucoma subjects.
Keywords: genetics • gene modifiers