May 2006
Volume 47, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2006
Effects of Photodynamic Treatment on Ocular Perfussion and Macular Functions
Author Affiliations & Notes
  • Y. Bardak
    Suleyman Demirel University, Medical School, Isparta, Turkey
    Ophthalmology,
  • O. Çekiç
    Suleyman Demirel University, Medical School, Isparta, Turkey
    Ophthalmology,
  • A. Arslanyıldız
    Suleyman Demirel University, Medical School, Isparta, Turkey
    Ophthalmology,
  • F. Kendir
    Suleyman Demirel University, Medical School, Isparta, Turkey
    Ophthalmology,
  • A. Yesildağ
    Suleyman Demirel University, Medical School, Isparta, Turkey
    Radiology,
  • Footnotes
    Commercial Relationships  Y. Bardak, None; O. Çekiç, None; A. Arslanyıldız, None; F. Kendir, None; A. Yesildağ, None.
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science May 2006, Vol.47, 342. doi:
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      Y. Bardak, O. Çekiç, A. Arslanyıldız, F. Kendir, A. Yesildağ; Effects of Photodynamic Treatment on Ocular Perfussion and Macular Functions . Invest. Ophthalmol. Vis. Sci. 2006;47(13):342.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To investigate the effects of photodynamic treatment (PDT) on ocular blood flow and macular functions in patients with age–related macular degeneration.

Methods: : PDT with verteporfine was applied to 18 subjects (mean age, 70 years) with subfoveal choroidal neovascularization due to age–related macular degeneration. All patients were assessed in a masked fashion for ocular hemodynamic parameters (color Doppler imaging), visual acuity (distant [Snellen] and near [Rosenbaum Vision Screener]), contrast sensitivity (Robin Contrast Sensitivity Test), stereopsis (Titmus test), 5–degree macular threshold (Humphrey Field Analyser) and colour vision (Ishihara charts). Measurments were performed in treated and fellow eyes within 24 hours before and 1 week, 1, 2, 3 months after PDT.

Results: : At baseline, hemodynamic parameters of ophthalmic artery, posterior ciliary arteries and central retinal artery were not different between treated and fellow eyes (P>0.26). At each time point, PDT did not change any hemodynamic parameters (P>0.16). Distant visual acuity was found improved only at 1 month (P=0.01) whereas near vision started to improve at first week (P=0.04) but decreased at 3 months after PDT (P=0.17). Contrast sensitivity and stereopsis improved at first month (P=0.01 and P=0.02, respectively) and second month (P=0.02 and P=0.007, respectively). At 1 week, there was a positive correlation between distant vision and stereopsis (rho=0.79, P<0.001). Distant vision positively correleted to diastolic flow velocity in central retinal artery (rho=0.85, P=0.008). At 1 month, stereopsis exhibited positive correlation with distant (rho=0.57, P=0.01) and near vision (rho=0.62, P<0.001).

Conclusions: : PDT was not associated with change in blood flow but macular functions in patients with age–related macular degeneration. Distant and near vision, contrast sensitivity and stereopsis temporarily improved following PDT.

Keywords: age-related macular degeneration • photodynamic therapy • clinical (human) or epidemiologic studies: treatment/prevention assessment/controlled clinical trials 
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