Purchase this article with an account.
A.G. Konstas, S. Lake, A.I. Economou, K. Kaltsos, J.N. Jenkins, W.C. Stewart; 24–Hour Control With the Latanoprost/Timolol Maleate Fixed Combination versus Timolol Maleate . Invest. Ophthalmol. Vis. Sci. 2006;47(13):442.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To evaluate 24–hour intraocular pressure control with evening dosing of the latanoprost/timolol maleate fixed combination versus timolol maleate in patients with primary open–angle glaucoma.
A two–period, observer–masked, crossover, randomized, active–controlled comparison. After an appropriate 4–6 week medicine free period, qualified patients were randomized to either placebo dosed in the morning with the latanoprost/timolol maleate fixed combination dosed in the evening or timolol dosed twice daily for eight weeks. Patients were then switched to the opposite treatment for eight weeks. At baseline and at the end of each treatment period patients underwent intraocular pressure measurements at 06:00, 10:00, 14:00, 18:00, 22:00 and 02:00 hours.
Both treatments reduced the intraocular pressure from untreated baseline at each time point and for the 24–hour curve (P < 0.0001). When treatments were compared, the latanoprost/timolol maleate fixed combination decreased the intraocular pressure more than timolol maleate at each time point and for the 24–hour curve (2.9 mm Hg), as well as provided a lower absolute intraocular pressure at each time point and for the 24–hour curve (P < 0.0001). Several side effects were observed more often with the latanoprost/timolol maleate fixed combination including: ocular stinging (P = 0.05), conjunctival hyperemia (P = 0.02) and ocular itching (P = 0.04).
This study suggests that evening dosing of the latanoprost/timolol maleate fixed combination provides better intraocular pressure control than timolol maleate over 24–hours, and demonstrates a narrower range of intraocular pressure fluctuation, in primary open–angle glaucoma patients.
This PDF is available to Subscribers Only