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C. Park, M. Sung, T. Park, Y.–H. Ohn; Correlation Between Morphological and Functional Results by Retinal Thickness Analyzer and Multifocal Electroretinogram in Patients With Diabetic Macular Edema . Invest. Ophthalmol. Vis. Sci. 2006;47(13):1001.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the correlation between the central retinal thickness measured by retinal thickness analyzer(RTA) and central retinal function recorded by multifocal electroretinogram(mfERG).
RTA(Version A, Talia Technology Ltd., Neve Ilan, Israel) images and mfERG(VERISTM, EDI, San Mateo, CA) responses were obtained from 20 eyes of 10 patients with diabetic macular edema and 10 eyes of 10 normal subjects. The central retinal thickness was measured using RTA and correlated with the responses of mfERG. These results were analyzed with Pearson's correlation and Mann–Whitney U test.
The central retinal thickness(286.96±76.35microm) in patients with diabetic macular edema was increased significantly compared with that(185.29±11.09microm) in normal subjects. The mfERG responses showed decreased amplitudes and increased latencies at central retina in patients with diabetic macular edema compared with normal subjects. Central retinal thickness and N1, P1 amplitudes of the mfERG were inversely correlated(r=–0.681, r=–0.494), however central retinal thickness and P1 latency of the mfERG were directly correlated(r=0.627).
The mfERG changes were correlated significantly with morphological changes measured by RTA. The RTA and mfERG may be useful tools to detect diabetic macular edema quantitatively and functionally, and provide objective assessment to evaluate diabetic macular edema.
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