May 2006
Volume 47, Issue 13
ARVO Annual Meeting Abstract  |   May 2006
Omega Fatty Acids and Age–Related Macular Degeneration in the Eureye Study
Author Affiliations & Notes
  • A.E. Fletcher
    Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom
  • I. Young
    The Queen's University of Belfast, Belfast, United Kingdom
  • U. Chakravarthy
    Centre for Vision Science,
    The Queen's University of Belfast, Belfast, United Kingdom
  • P. deJong
    KNAW, Netherlands Ophthalmic Research Institute, Amsterdam, The Netherlands
  • M. Rahu
    Epidemiology, The National Institute for Health Development, Tallinn, Estonia
  • J. Seland
    Ophthalmology, University of Bergen, Bergen, Norway
  • G. Soubrane
    Clinique Ophthalmologique, University de Creteil, Paris, France
  • L. Tomazzoli
    Clinica Oculistica, Universita degli Studi di Verona, Verona, Italy
  • F. Topouzis
    Ophthalmology, Aristotle University of Thessaloniki, Thessaloniki, Greece
  • J. Vioque
    Dpto. Salud Publica, Universidad Miguel Hernandez, Alicante, Spain
  • Footnotes
    Commercial Relationships  A.E. Fletcher, None; I. Young, None; U. Chakravarthy, None; P. deJong, None; M. Rahu, None; J. Seland, None; G. Soubrane, None; L. Tomazzoli, None; F. Topouzis, None; J. Vioque, None.
  • Footnotes
    Support  The European Commission Vth Framework (QLK 6–CT–1999–02094), The Macular Diseases Society of the UK, The Pocklington Trust, UK
Investigative Ophthalmology & Visual Science May 2006, Vol.47, 1132. doi:
  • Views
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      A.E. Fletcher, I. Young, U. Chakravarthy, P. deJong, M. Rahu, J. Seland, G. Soubrane, L. Tomazzoli, F. Topouzis, J. Vioque; Omega Fatty Acids and Age–Related Macular Degeneration in the Eureye Study . Invest. Ophthalmol. Vis. Sci. 2006;47(13):1132.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements

Purpose: : To invesigate the association between omega fatty acids and age–related macular degeneration (AMD)

Methods: : We conducted a nested case–control study in the 7 country population–based EUREYE study. Of 158 cases with AMD, 149 (46 geographic atrophy, 103 neovascular) had stored blood samples. Cases were matched by country, sex and age (frequency matched within 1 year)with controls who had no signs of early ARM or AMD. Bloods were analysed by capillary gas–liquid chromatography for omega fatty acids: linoleic (LA), alpha linolenic (ALA), eicosapentaenoic (EPA), docosahexanoic(DHA). Statistical analysis was by logistic regression adjusted for potential counfounders (smoking, myocardial infarction, diabetes, serum antioxidants).

Results: : ALA was signficantly associated with AMD in both univariate and adjusted analyses with OR for the highest versus lowest tertile of 0.25 (0.11, 0.52), p = 0.0001. Increasing quartiles of LA were associated with decreasing odds of AMD, eg. OR for highest versus lowest quartile of 0.45 (0.23, 0.89) p = 0.02. DHA showed a reduced association for highest versus lowest quartile but was not signfiicant, OR 0.55 (0.27, 1.09) p = 0.09. EPA was not associated with AMD.

Conclusions: : In contrast to studies based only on dietary analyses, our results based on blood analysis showed strong inverse associations with higher blood levels of LA and ALA.

Keywords: clinical (human) or epidemiologic studies: risk factor assessment • nutritional factors 

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.