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S. Milazzo, F. Denimal, B. Jany; Link Between Trypan Blue And Posterior Capsule Opacification . Invest. Ophthalmol. Vis. Sci. 2006;47(13):667.
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To describe clinical findings, long term complications, incidence of posterior capsule opacification (PCO) after cataract surgery using trypan blue, because this dye is cytotoxic in vitro.
A retrospective study included 20 eyes of 20 patients having mature cataract. The surgical procedure used trypan blue for anterior capsulorhexis. Phacoemulsification and implantation were without peroperative complication. The mean follow–up was of 3.2 years(2 to 5 years). Visual acuity, endothelial cell count, anterior chamber reaction, intraocular pressure, IOL deposits,PCO were documented at 1 week, 1 and 6 months, and every year.
There was no incidence about endothelial cell count, or intraocular presuure. No IOL deposits were observed. 5 eyes presented PCO.
Trypan blue 1% seems to be safe, so no incidence, particularly a decrease of PCO because an eventual cytotoxicity, was observed at long term.
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