May 2006
Volume 47, Issue 13
ARVO Annual Meeting Abstract  |   May 2006
Optic Neuropathy and Alpha–2 Antiplasmin
Author Affiliations & Notes
  • J.G. McHenry
    Ophthalmology, UT Southwestern, Dallas, TX
  • J.R. Younger
    Ophthalmology, UT Southwestern, Dallas, TX
  • Footnotes
    Commercial Relationships  J.G. McHenry, None; J.R. Younger, None.
  • Footnotes
    Support  Research to Prevent Blindness
Investigative Ophthalmology & Visual Science May 2006, Vol.47, 731. doi:
  • Views
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      J.G. McHenry, J.R. Younger; Optic Neuropathy and Alpha–2 Antiplasmin . Invest. Ophthalmol. Vis. Sci. 2006;47(13):731.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements

Purpose: : We report 5 patients with optic neuropathy with elevated alpha–2 antiplasmin levels to show a previously unrecognized potential cause of ischemic optic neuropathy.

Methods: : We reviewed the cases of 5 patients presenting to a University Eye Clinic with vision loss whose laboratory evaluation revealed an elevated alpha–2 fraction on their serum protein electrophoresis and subsequent elevated alpha–2 antiplasmin levels.

Results: : Patient age ranged from 45 to 76 years old. Three patients were female and 2 were male. Visual acuity ranged from 20/20 to counting fingers and visual field defects included paracentral, altitudinal and centrocecal defects. Although all patients showed gradual improvement on repeat visual fields, no defects completely resolved. All patients had signs and symptoms of ischemic optic neuropathy including painless visual loss with either optic disc pallor or segmental hemorrhage. Concurrent conditions included thyroid disease(1 patient) and ethambutal use in a patient whose central scotoma did not improve one year after discontinuing the medication.

Conclusions: : Alpha–2 antiplasmin elevation may increase the risk of thrombosis. This may lead to ischemic complications in patients with already compromised ciliary circulation. Patients with ischemic optic neuropathy should be evaluated for alpha–2 antiplasmin elevation.

Keywords: neuro-ophthalmology: optic nerve • optic disc • visual fields 

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.