Purchase this article with an account.
J. Combes, L. Hoffart, F. Galland, N. Wotawa, G.S. Masson, F. Chavane, E. Castet, B. Ridings, J. Conrath; Effects of Visual Scotomas on the Retinotopic Organization in Age–Related Macular Degeneration Patients . Invest. Ophthalmol. Vis. Sci. 2006;47(13):797.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
We used functional magnetic resonance imaging (fMRI) to map the retinotopic organization of visual cortical areas and to measure the localization and surface of the cortical projections of visual scotomas in patients with age–related macular degeneration.
fMRI data were acquired on 2 subjects with bilateral age–related macular degeneration. Retinotopic maps were first reconstructed using classical mapping techniques. Second, a block paradigm consisting of a grey background alternating with a fullfield, flickering checkerboard was used to stimulate the complete central (19.5°) visual field. In both experiments, conditions with 4 peri–foveal scotomas of different sizes and centered at different eccentricities were interleaved. Subjects were asked to fixate a central cross and to report transient colour changes of the latter at random intervals, ensuring that they maintained fixation and attention at the center of the visual field. A Brucker 3T scanner equiped with head coil and custom optical system was used to acquire sets of echo–planar images of 20 occipital coronal slices within a RT of 2111msec and an 8 mm3 voxel resolution. Surface models of each subject’s occipital lobes were constructed using Brainvisa software from a sagital T1 weighted image with a 1mm3 voxel resolution. The cortical models were then inflated to get unfolded surfaces. Statistical analyses of the functional data were made through General Linear Models under SPM99, and the responses amplitudes were finally assigned to the cortical reconstructed surfaces.
With our retinotopic visual areas mapping method, we could identify cortical projections of each central visual scotoma by the use of eccentricity and polar angle retinotopic maps. This results were compared with the known values of radius, eccentricity and surface of scotomas in the visual field or acquired by microperimetry. We also measured surfaces of the inactivated cortical zones
We developed a quick retinotopic cortical areas mapping method, which allows us to measure the cortical surface and localization of visual scotoma cortical projections in age–related macular degeneration patients.
This PDF is available to Subscribers Only