May 2006
Volume 47, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2006
High–Speed Optical Coherence Tomography Mapping of Corneal Opacities
Author Affiliations & Notes
  • R.N. Khurana
    Ophthalmology, Doheny Eye Institute, Los Angeles, CA
  • Y. Li
    Ophthalmology, Doheny Eye Institute, Los Angeles, CA
  • M.M. Lai
    Ophthalmology, Doheny Eye Institute, Los Angeles, CA
  • D. Huang
    Ophthalmology, Doheny Eye Institute, Los Angeles, CA
  • Footnotes
    Commercial Relationships  R.N. Khurana, None; Y. Li, None; M.M. Lai, None; D. Huang, Carl Zeiss Meditec, Inc, F; Optical Coherence Tomography, P.
  • Footnotes
    Support  P30 EY03040
Investigative Ophthalmology & Visual Science May 2006, Vol.47, 1325. doi:
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    • Get Citation

      R.N. Khurana, Y. Li, M.M. Lai, D. Huang; High–Speed Optical Coherence Tomography Mapping of Corneal Opacities . Invest. Ophthalmol. Vis. Sci. 2006;47(13):1325.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

To evaluate the accuracy of high speed optical coherence tomography (OCT) in measuring corneal thickness in corneas with opacities.

 
Methods:
 

Central corneal thickness was prospectively measured in sixteen consecutive eyes with corneal opacities using a high–speed corneal OCT prototype (Carl Zeiss Meditec Inc., Dublin, CA), Orbscan II (Bausch & Lomb Inc., Rochester, NY) and ultrasound pachymetry (Sonogage, Cleveland, OH). The OCT system has a speed of 2000 axial scans/sec and operates at 1.3 micron wavelength. Paired t–tests were used to compare measurements between pacymetry, Orbscan II, and OCT.

 
Results:
 

In patients with central opacities (n=11), there is a difference of 157.1 µm ±142 (p=0.004) between ultrasound and Orbscan II while the difference is –10.8 µm ±18 (p=0.075) between ultrasound and OCT. Figure 1 demonstrates a scatter plot of pachymetry in cases with central opacity. There is one case with a dense corneal scar where Orbscan II was unable to measure corneal topography nor corneal thickness while OCT and ultrasound were able to. In patients with off–central opacities (n=4), there is no statistically significant difference between ultrasound, Orbscan II and OCT. OCT measurements of epithelial thickness, scar depth and corneal thickness maps were also demonstrated.

 
Conclusions:
 

High speed OCT provides reliable pachymetry mapping while Orbscan II significantly underestimates corneal thickness in the setting of corneal scars. OCT could be valuable in the planning laser and surgical treatment of corneal scars.  

 
Keywords: cornea: clinical science • imaging/image analysis: clinical • detection 
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