May 2006
Volume 47, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2006
Functional Involvement of the RAGE Receptor System in PVR Propagation
S. Hoffmann; S. He; Y.H. Kim; C. Spee; G.K. Lang; G.E. Lang; S.J. Ryan; D.R. Hinton
Author Affiliations & Notes
  • S. Hoffmann
    Ophthalmology, Doheny Eye Institute, Los Angeles, CA
  • S. He
    Ophthalmology, Doheny Eye Institute, Los Angeles, CA
    Pathology, University of Southern California, Los Angeles, CA
  • Y.H. Kim
    Ophthalmology, Doheny Eye Institute, Los Angeles, CA
  • C. Spee
    Ophthalmology, Doheny Eye Institute, Los Angeles, CA
  • G.K. Lang
    Universitaetsaugenklinik Ulm, Ulm, Germany
  • G.E. Lang
    Universitaetsaugenklinik Ulm, Ulm, Germany
  • S.J. Ryan
    Ophthalmology, Doheny Eye Institute, Los Angeles, CA
  • D.R. Hinton
    Ophthalmology, Doheny Eye Institute, Los Angeles, CA
    Pathology, University of Southern California, Los Angeles, CA
  • Footnotes
    Commercial Relationships  S. Hoffmann, None; S. He, None; Y.H. Kim, None; C. Spee, None; G.K. Lang, None; G.E. Lang, None; S.J. Ryan, None; D.R. Hinton, None.
  • Footnotes
    Support  NIH grants EY03040 and EY01545, Research to Prevent Blindness and the Arnold and Mabel Beckman Foundation
Investigative Ophthalmology & Visual Science May 2006, Vol.47, 1434. doi:
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      S. Hoffmann, S. He, Y.H. Kim, C. Spee, G.K. Lang, G.E. Lang, S.J. Ryan, D.R. Hinton; Functional Involvement of the RAGE Receptor System in PVR Propagation . Invest. Ophthalmol. Vis. Sci. 2006;47(13):1434.

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Abstract

Purpose: : To investigate the involvement of the pro–inflammatory RAGE receptor system and its ligands in proliferative vitreoretinopathy (PVR).

Methods: : Surgically removed PVR membranes were immunohistochemically stained for the expression of the RAGE receptor system and its ligands S100B, HMGB–1, S100A12, S100A7 and S100A8. Furthermore, functional aspects of S100B and HMGB–1 on the proliferation, migration and smooth muscle actin positivity of retinal pigmented epithelial cells (RPE) were evaluated.

Results: : The RAGE receptor and its ligands S100B and S100A12 were strongly expressed in the excised PVR membranes. For HMGB–1 and S100A8, a weaker expression was seen, while S100A7 was not detected. RAGE was colocalized stromgly with RPE cells by double labeling for cytokeratin. Both HMGB–1 and S100B increased the proliferation and migration of RPE cells (p<0.05) in vitro. Furthermore, HMGB–1 induced a strong smooth muscle actin positivity of RPE cells after an exposure time of 5 days.

Conclusions: : The RAGE multiligand system with its ligands S100A12, S100B, S100A8 and HMGB–1 may be involved in the propagation of PVR and should be further evaluated for feasibility as a therapeutic target.

Keywords: proliferative vitreoretinopathy • inflammation • pathobiology 
© 2006, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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