May 2006
Volume 47, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2006
A Novel Material for Scleral Buckle Procedures – An Experimental Study
M.G. Aly; H. Yamamoto; E.M. Espana; M.A. Orozco; M. Aguilar; E. Arrieta; L. Pinchuk; J. Martin; W. Smiddy; J.–M. Parel
Author Affiliations & Notes
  • M.G. Aly
    Ophthalmic Biophysics Center,Bascom Palmer Eye Institute., University of Miami Miller School of Medicine, Miami, FL
    Ophthalmology Department, Ain Shams University, Cairo, Egypt
  • H. Yamamoto
    Ophthalmic Biophysics Center,Bascom Palmer Eye Institute., University of Miami Miller School of Medicine, Miami, FL
  • E.M. Espana
    Ophthalmic Biophysics Center,Bascom Palmer Eye Institute., University of Miami Miller School of Medicine, Miami, FL
  • M.A. Orozco
    Ophthalmic Biophysics Center,Bascom Palmer Eye Institute., University of Miami Miller School of Medicine, Miami, FL
    Dept. of Biomedical Engineering, College of Engineering, Univ. of Miami, Miami, FL
  • M. Aguilar
    Ophthalmic Biophysics Center,Bascom Palmer Eye Institute., University of Miami Miller School of Medicine, Miami, FL
    Dept. of Biomedical Engineering, College of Engineering, Univ. of Miami, Miami, FL
  • E. Arrieta
    Ophthalmic Biophysics Center,Bascom Palmer Eye Institute., University of Miami Miller School of Medicine, Miami, FL
    Univ. Hospital of Los Andes, Merida, Venezuela
  • L. Pinchuk
    Dept. of Biomedical Engineering, College of Engineering, Univ. of Miami, Miami, FL
    InnFocus LLC, Miami, FL
  • J. Martin
    InnFocus LLC, Miami, FL
  • W. Smiddy
    Ophthalmic Biophysics Center,Bascom Palmer Eye Institute., University of Miami Miller School of Medicine, Miami, FL
  • J.–M. Parel
    Ophthalmic Biophysics Center,Bascom Palmer Eye Institute., University of Miami Miller School of Medicine, Miami, FL
    Univ. of Liege, CHU Sart–Tilman, Liege, Belgium
  • Footnotes
    Commercial Relationships  M.G. Aly, InnFocus LLC, Miami, FL, F; H. Yamamoto, InnFocus LLC, Miami, FL, F; E.M. Espana, InnFocus LLC, Miami, FL, F; M.A. Orozco, InnFocus LLC, Miami, FL, F; M. Aguilar, InnFocus LLC, Miami, FL, F; E. Arrieta, InnFocus LLC, Miami, FL, F; L. Pinchuk, InnFocus LLC, Miami, FL, I; InnFocus LLC, Miami, FL, E; InnFocus LLC, Miami, FL, P; J. Martin, InnFocus LLC, Miami, FL, E; W. Smiddy, InnFocus LLC, Miami, FL, F; J. Parel, InnFocus LLC, F; InnFocus LLC, Miami, FL, P.
  • Footnotes
    Support  NIH Center Grant P30–EY014801; InnFocus LLC; Florida Lions Eye Bank; Research to Prevent Blindness; Henri and Flore Lesieur Foundation. NIH Center Grant P30–EY014801; InnFocus LLC; Florida Lions Eye Bank; Research to Prevent Blindness; Henri and Flore Lesieur Foundation.
Investigative Ophthalmology & Visual Science May 2006, Vol.47, 1487. doi:
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      M.G. Aly, H. Yamamoto, E.M. Espana, M.A. Orozco, M. Aguilar, E. Arrieta, L. Pinchuk, J. Martin, W. Smiddy, J.–M. Parel; A Novel Material for Scleral Buckle Procedures – An Experimental Study . Invest. Ophthalmol. Vis. Sci. 2006;47(13):1487.

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Abstract

Purpose: : To evaluate in normal NZW rabbits the surgical and clinical outcomes of scleral buckles made of poly(styrene–b–isobutylene–b–styrene)(SIBS). SIBS is a novel polymer used in paclitaxel eluting stents (TAXUSTM, Boston Scientific).

Methods: : In 6 eyes, a segmental circumferential buckle was implanted under an encircling band that was secured by a sleeve, all made of SIBS (InnFocus LLC, Miami, FL). A control group of 5 eyes underwent implantation of identically shaped implants made of PDMS (Labtician Inc, Canada; Silicone Band #240, Sleeve #3083, and Buckle #219). Slit lamp evaluation was done at POD 3, 14, 21, 28, 56, 120, 180. Fundus evaluation under anesthesia was done immediately after surgery and together with slit lamp evaluation and ophthalmoscopy at POD 7, 42, 90, 180, and then monthly thereafter until 9 months.

Results: : Average surgery time was 84+/–9 min. Intraoperative retinal perforation by suture needle occurred in 1 SIBS and in 4 PDMS eyes resulting in a limited hemorrhage in 2 of the PDMS eyes which subsided intraoperatively. No retinal detachment, vitreous opacities, panophthalmitis or extrusion were observed in any of the operated eyes. During the first 7 weeks, the average conjunctival hyperemia was 0.2 for SIBS and 1.15 for PDMS; at 6 month, it was 0 for SIBS and 0.3 for PDMS; while at 9 months it was 0 for both groups. One of the SIBS implanted eyes showed anterior migration of the sleeve at 6 months due to slippage of 1 of 4 securing sutures. PDMS implants showed surface conjunctival neovessels. None of the SIBS implanted eyes showed any inflammatory reaction or neovascularization suggesting good biocompatibility. Buckling effect was slightly higher among the SIBS implanted eyes but not statistically significant.

Conclusions: : SIBS scleral buckle implants were found to be biocompatible in the rabbit model. As SIBS allows for controlled drug release, it could become useful in the treatment of complicated retinal detachment and recurrent PVR.

Keywords: retinal detachment • sclera • retina 
© 2006, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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