May 2006
Volume 47, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2006
Glutamate NMDA Receptor 1 Subunit Expression Is Increased in the Lateral Geniculate Nucleus of Experimental Glaucoma
Y. Yucel; A. Darabie; S. Wang; P.L. Kaufman; N. Gupta
Author Affiliations & Notes
  • Y. Yucel
    Ophthalmic Pathology Laboratory, Univ of Toronto/St. Michael's Hospital, Toronto, ON, Canada
    Ophthalmology & Vision Sciences, Laboratory Medicine & Pathobiology, Univ of Toronto/St. Michael's Hospital Research Institute, Toronto, ON, Canada
  • A. Darabie
    Ophthalmic Pathology Laboratory, Univ of Toronto/St. Michael's Hospital, Toronto, ON, Canada
    Ophthalmology & Vision Sciences, Laboratory Medicine & Pathobiology, Univ of Toronto/St. Michael's Hospital Research Institute, Toronto, ON, Canada
  • S. Wang
    Ophthalmic Pathology Laboratory, Univ of Toronto/St. Michael's Hospital, Toronto, ON, Canada
    Ophthalmology & Vision Sciences, Laboratory Medicine & Pathobiology, Univ of Toronto/St. Michael's Hospital Research Institute, Toronto, ON, Canada
  • P.L. Kaufman
    Ophthalmology & Vision Sciences, University of Wisconsin, Madison, WI
  • N. Gupta
    Ophthalmology & Vision Sciences, Laboratory Medicine & Pathobiology, Univ of Toronto/St. Michael's Hospital Research Institute, Toronto, ON, Canada
    Glaucoma and Nerve Protection Unit, St. Michael's Hospital, Toronto, ON, Canada
  • Footnotes
    Commercial Relationships  Y. Yucel, None; A. Darabie, None; S. Wang, None; P.L. Kaufman, None; N. Gupta, None.
  • Footnotes
    Support  CIHR/SME (NG, YY); NEI–EY02698, RPB, RRF (PLK)
Investigative Ophthalmology & Visual Science May 2006, Vol.47, 1555. doi:
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      Y. Yucel, A. Darabie, S. Wang, P.L. Kaufman, N. Gupta; Glutamate NMDA Receptor 1 Subunit Expression Is Increased in the Lateral Geniculate Nucleus of Experimental Glaucoma . Invest. Ophthalmol. Vis. Sci. 2006;47(13):1555.

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Abstract

Purpose: : To determine whether the NMDA receptor implicated in glutamate excitotoxicity, is over–expressed in the lateral geniculate nucleus (LGN) of experimental glaucoma.

Methods: : Eight adult cynomolgus monkeys with unilateral experimental glaucoma for up to 11 months duration, and 3 normal monkeys were studied. LGN layers were examined following immunocytochemical staining with antibody to NMDA receptor 1 subunit (NMDA R1).

Results: : In the normal LGN, NMDA R1 immunoreactivity was present, and evenly distributed across layers 1 to 6. In glaucomatous LGN, NMDA R1 was also present in all 6 layers, but NMDA R1 expression was increased in layers connected to the glaucomatous eye compared with those connected to the non–glaucomatous eye.

Conclusions: : Glutamate NMDA R1 receptor is increased in LGN layers connected to glaucomatous eyes in monkeys. This finding suggests that glutamate is involved in glaucomatous CNS degeneration, and may be relevant to treatment strategies in glaucoma.

Keywords: neuroprotection • pathology: experimental • thalamus/lateral geniculate nucleus 
© 2006, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2024 Association for Research in Vision and Ophthalmology.
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