May 2006
Volume 47, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2006
Topical Human Amniotic Fluid vs. Potent Antiangiogenesis Protein in the Inhibition of Induced Corneal Neovascularization
S. Sikder; S.P. Herretes; E. Duh; O. Suwan–Apichon; J.M. G. Reyes; M. Cano; P. Gehlbach; E. Gurewitsch; A. Behrens
Author Affiliations & Notes
  • S. Sikder
    College of Medicine, University of Arizona, Tucson, AZ
  • S.P. Herretes
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD
  • E. Duh
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD
  • O. Suwan–Apichon
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD
  • J.M. G. Reyes
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD
  • M. Cano
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD
  • P. Gehlbach
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD
  • E. Gurewitsch
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD
  • A. Behrens
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD
  • Footnotes
    Commercial Relationships  S. Sikder, None; S.P. Herretes, None; E. Duh, None; O. Suwan–Apichon, None; J.M.G. Reyes, None; M. Cano, None; P. Gehlbach, None; E. Gurewitsch, None; A. Behrens, None.
  • Footnotes
    Support  Research to Prevent Blindness
Investigative Ophthalmology & Visual Science May 2006, Vol.47, 1650. doi:
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      S. Sikder, S.P. Herretes, E. Duh, O. Suwan–Apichon, J.M. G. Reyes, M. Cano, P. Gehlbach, E. Gurewitsch, A. Behrens; Topical Human Amniotic Fluid vs. Potent Antiangiogenesis Protein in the Inhibition of Induced Corneal Neovascularization . Invest. Ophthalmol. Vis. Sci. 2006;47(13):1650.

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Abstract

Purpose: : To evaluate the efficacy of topical human amniotic fluid (HAF) vs. pigment epithelium–derived factor (PEDF) in arresting corneal neovascularization (CNV).

Methods: : Hydron pellets containing basic–fibroblast growth factor (bFGF) (Groups I –IV) or bFGF/PEDF (Group V) were implanted in 25 mice using an intrastromal micropocket assay. Topical treatment differed in each group: Group I received saline; II, pre–term HAF; III, term HAF; and IV/V, no treatment. The CNV area (mm2) was evaluated on day 6.

Results: : HAF treatment showed a significant decrease in CNV compared to saline (I: 6.38± 0.82; II: 1.03 ± 0.64; III: 1.33 ± 0.74; P < .016). The addition of PEDF to bFGF also demonstrated a reduction in CNV (IV: 8.52 ± 3.91; V: 1.68 ± 1.10; P < .016). Groups II and III were statistically similar and also similar to Group V (P > .421).

Conclusions: : Topical HAF appears to be as effective as PEDF in preventing corneal neovascularization.

Keywords: neovascularization • cornea: basic science • inflammation 
© 2006, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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