May 2006
Volume 47, Issue 13
ARVO Annual Meeting Abstract  |   May 2006
Human Lens Capsule Thickness as a Function of Age and Location Along the Sagittal Lens Perimeter
Author Affiliations & Notes
  • R. Michael
    Institut Universitari Barraquer, Barcelona, Spain
  • R.I. Barraquer
    Institut Universitari Barraquer, Barcelona, Spain
  • R. Abreu
    Institut Universitari Barraquer, Barcelona, Spain
  • J. Lamarca
    Institut Universitari Barraquer, Barcelona, Spain
  • F. Tresserra
    Institut Universitari Dexeus, Barcelona, Spain
  • Footnotes
    Commercial Relationships  R. Michael, None; R.I. Barraquer, None; R. Abreu, None; J. Lamarca, None; F. Tresserra, None.
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science May 2006, Vol.47, 1972. doi:
  • Views
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      R. Michael, R.I. Barraquer, R. Abreu, J. Lamarca, F. Tresserra; Human Lens Capsule Thickness as a Function of Age and Location Along the Sagittal Lens Perimeter . Invest. Ophthalmol. Vis. Sci. 2006;47(13):1972.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements

Purpose: : To investigate the variation in the thickness of the human lens capsule along the lens perimeter, as well as its changes with age.

Methods: : Altogether 26 human donor lenses, aged 12 to 103 years, were histologically processed. Sagittal sections were stained for collagen with periodic acid–Schiff (PAS). Serial images of the lens border were taken with a photomicroscope using a 25x objective. Capsular thickness was measured every 250 µm along the entire lens perimeter.

Results: : All studied capsules were thicker anteriorly, continuously increasing with age from 11 to 15 µm in average at the anterior lens pole. Maximal thickness was located at the anterior midperiphery, increasing with age from 13.5 to 16 µm. In most cases, there was a local thinning at a pre–equatorial zone, recovering to about 7 µm at the equator. The latter value, as well as the minimal thickness at the posterior pole (mean 3.5 µm) did not change with age, while the average thickness at the posterior periphery decreased from 9 to 4 µm.

Conclusions: : The human lens capsule thickness is maximal at the anterior midperiphery, which appears located central to the zonular insertion. It increases with age, especially at the anterior pole, while the midperipheral zone stabilizes or slightly decreases after the 7th decade. The anterior zonular insertion is actually related to a local pre–equatorial thinning, which remains unchanged with age. We did not find a posterior peripheral thickening, except in a few younger patients, with a modest relative maximum roughly at the equator. From here, the posterior capsule becomes progressively thinner and also diminishes with age, except for the thinnest but stable posterior pole.

Keywords: crystalline lens • microscopy: light/fluorescence/immunohistochemistry • presbyopia 

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.