May 2006
Volume 47, Issue 13
ARVO Annual Meeting Abstract  |   May 2006
Drusen, Good Visual Acuity and Lipids: Is There an Association?
Author Affiliations & Notes
  • R.P. Lee
    University of California, Berkeley, Berkeley, CA
  • G. Wu
    Ophthalmology, Stanford University School of Medicine, Stanford, CA
  • N. Nguyen
    University of California, Berkeley, Berkeley, CA
    Integrative Biology,
  • Footnotes
    Commercial Relationships  R.P. Lee, None; G. Wu, None; N. Nguyen, None.
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science May 2006, Vol.47, 2094. doi:
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      R.P. Lee, G. Wu, N. Nguyen; Drusen, Good Visual Acuity and Lipids: Is There an Association? . Invest. Ophthalmol. Vis. Sci. 2006;47(13):2094.

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      © ARVO (1962-2015); The Authors (2016-present)

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Lipid metabolism and its role as a risk factor in Age RelatedMacular Degeneration have been discussed in the literature.Recently, cholesterol lowering medications have been found tohave a possible protective effect in developing Age RelatedMacular Degeneration (AMD). However, there is no data on earlyAMD as manifested by drusen, good visual acuity, and its relationshipto serum lipids.


To evaluate the possible associationof elevated serum lipids in asymptomatic patients with drusenand good visual acuity.


We examined 32 patients ina retina practice with good visual acuity (20/20–20/70),with drusen as determined by slit lamp biomicroscopy, dilatedfundus exam, digital fundus photography (OIS, Winstation–XP3200, v.10.2.44), standard grid for ARM classification. Agerange of 50–90 years and serum lipids (mg/dl): total cholesterol(CH), High density lipoprotein (HDL), Low density lipoprotein(LDL), Triglycerides (TG). Exclusion criteria: diabetes, historyof macular disease.


32 patients: 17 F: 8M. 57 eyes,age range 50–86 yrs, avg= 69.2+ 11.17. CH =avg 199.4+37.37;HDL= 59.05 + 20.12; LDL= 111.9 + 31.73; TG =142.8 +67.55.  



Among patients with good visual acuity and drusen,lower cholesterol occurs in those patients with 20/50–20/70versus 20/20–20/40 vision. Our findings support the datafrom earlier studies where lower serum cholesterol is associatedwith early AMD. While Cholesterol may be a risk factor, therole of the other serum lipids is less clear in drusen formation.However, more work needs to be done on other serum markers inearly AMD.

Keywords: age-related macular degeneration • drusen • lipids 

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