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E. Pilotto, E. Midena, S. Vujosevic, A. Manfrè, E. Convento, P.P. Radin; Fundus Autofluorescence and Fundus Perimetry in Patients with Early Age–Related Macular Degeneration . Invest. Ophthalmol. Vis. Sci. 2006;47(13):2099.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate retinal sensitivity of macular area that shows variations in fundus autofluorescence (FAF) in patients with early age–related macular degeneration (AMD) with high risk characteristics (HRC).
The spatial distribution and intensity of FAF in eyes with early AMD were recorded with confocal scanning laser ophthalmoscope (Heidelberg Retina Angiograph, HRA). Retinal sensitivity was assessed by a microperimetry (fundus–related perimetry). Inclusion criteria were early AMD fundus changes with HRC (large drusen and focal hyperpigmentation), and visual acuity of 20/40 or better.
43 consecutive patients with HRC early AMD were prospectively studied. Retinal sensitivity progressively decreased from areas showing increased FAF to areas with reduced FAF (p<.001). The central area of increased FAF corresponding to large foveal drusen showed significant reduced sensitivity compared to the mean sensitivity of the macular area (p<.005). Microperimetry data significantly correlated with FAF changes in patients progressing toward advanced AMD.
Increased FAF in early AMD has a functional correlate. In retinal areas affected by early AMD changes with HRC retinal sensitivity deteriorates, exactly documenting the functional impact of these lesions. Both tests may be useful to monitor (and predict) AMD progression.
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