May 2006
Volume 47, Issue 13
Jump To...
Free
ARVO Annual Meeting Abstract  |   May 2006
Association Between Age–Related Macular Degeneration (AMD) Fundus Features and Foveolar Choroidal Circulation
T.I. Metelitsina; J.E. Grunwald; J.C. DuPont; G.–S. Ying; J. Alexander; R.E. Martin; K.M. Matias
Author Affiliations & Notes
  • T.I. Metelitsina
    Ophthalmology, University of Pennsylvania Medical School, Philadelphia, PA
  • J.E. Grunwald
    Ophthalmology, University of Pennsylvania Medical School, Philadelphia, PA
  • J.C. DuPont
    Ophthalmology, University of Pennsylvania Medical School, Philadelphia, PA
  • G.–S. Ying
    Ophthalmology, University of Pennsylvania Medical School, Philadelphia, PA
  • J. Alexander
    Ophthalmology, University of Pennsylvania Medical School, Philadelphia, PA
  • R.E. Martin
    Ophthalmology, University of Pennsylvania Medical School, Philadelphia, PA
  • K.M. Matias
    Ophthalmology, University of Pennsylvania Medical School, Philadelphia, PA
  • Footnotes
    Commercial Relationships  T.I. Metelitsina, None; J.E. Grunwald, None; J.C. DuPont, None; G. Ying, None; J. Alexander, None; R.E. Martin, None; K.M. Matias, None.
  • Footnotes
    Support  NIH EY012769 HIGHWIRE EXLINK_ID="47:5:2169:1" VALUE="EY012769" TYPEGUESS="GEN" /HIGHWIRE and EY001583 HIGHWIRE EXLINK_ID="47:5:2169:2" VALUE="EY001583" TYPEGUESS="GEN" /HIGHWIRE , Vivian S. Lasko Research Fund, Nina C. Mackall Trust, Research to Prevent Blindness
Investigative Ophthalmology & Visual Science May 2006, Vol.47, 2169. doi:
  • Views
  • Share
  • Tools
    • Alerts
      User Alerts
      You are adding an alert for:
      Association Between Age–Related Macular Degeneration (AMD) Fundus Features and Foveolar Choroidal Circulation
      You will receive an email whenever this article is corrected, updated, or cited in the literature. You can manage this and all other alerts in My Account
      The alert will be sent to:
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation
      Citation

      T.I. Metelitsina, J.E. Grunwald, J.C. DuPont, G.–S. Ying, J. Alexander, R.E. Martin, K.M. Matias; Association Between Age–Related Macular Degeneration (AMD) Fundus Features and Foveolar Choroidal Circulation . Invest. Ophthalmol. Vis. Sci. 2006;47(13):2169.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

      ×
    • Get Permissions
  • Supplements
Abstract
 
Purpose:
 

To investigate the relationship between typical funduscopic features of AMD and foveolar choroidal circulation in patients with AMD.

 
Methods:
 

Measurements of relative choroidal blood velocity (ChBVel), volume (ChBVol) and flow (ChBFlow) in the center of the fovea were obtained in 181 study eyes of 134 patients with AMD using laser Doppler flowmeter (Oculix instrument). All study eyes had visual acuity of 20/40 or better and no signs of choroidal neovascularization (CNV). Presence of RPE hypertrophy and RPE depigmentation, drusen size and number, % area covered by drusen were assessed from color fundus photographs in a masked fashion by trained graders. Multivariate linear regression analysis was carried out with adjustments for significant covariates (age, intraocular pressure and perfusion pressure for ChBVel; age and intraocular pressure for ChBVol; age for ChBFlow). The correlation between paired eyes from the same subject was adjusted by using the generalized estimating equations (GEE). Results of choroidal circulatory parameters are shown in arbitrary units (AU).

 
Results:
 

 

Image not available
View OriginalDownload Slide
Image not available
View OriginalDownload Slide

 
Conclusions:
 

Clinical AMD features related with poor visual prognosis are generally associated with decreased ChBFlow. As shown in the above table the changes in flow are mostly due to changes in ChBVol.

 
Keywords: age-related macular degeneration • drusen • retinal pigment epithelium 
© 2006, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×
This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy.Accept