May 2006
Volume 47, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2006
The Relationship Between Retrobulbar and Choroidal Hemodynamics in Non–Neovascular Age–Related Macular Degeneration
E. Rechtman; A. Harris; T.A. Ciulla; R.P. Danis; B. Siesky; E. Brizendine; D. Sines; C.W. Yung; O. Geyer; H.J. Garzozi
Author Affiliations & Notes
  • E. Rechtman
    Ophthalmology, Carmel Medical Center, Haifa, Israel
  • A. Harris
    Ophthalmology, Indiana University School of Medicine, Indianapolis, IN
  • T.A. Ciulla
    Ophthalmology, Midwest Eye Institute, Indianapolis, IN
  • R.P. Danis
    Ophthalmology and Visual Sciences, UW Fundus Photograph Reading Center, University of Wisconsin–Madison, Madison, WI
  • B. Siesky
    Ophthalmology, Indiana University School of Medicine, Indianapolis, IN
  • E. Brizendine
    Division of Biostatistics, Indiana University, Indianapolis, IN
  • D. Sines
    Ophthalmology, Indiana University School of Medicine, Indianapolis, IN
  • C.W. Yung
    Ophthalmology, Indiana University School of Medicine, Indianapolis, IN
  • O. Geyer
    Ophthalmology, Carmel Medical Center, Haifa, Israel
  • H.J. Garzozi
    Ophthalmology, Bnai Zion Medical Center, Haifa, Israel
  • Footnotes
    Commercial Relationships  E. Rechtman, None; A. Harris, None; T.A. Ciulla, None; R.P. Danis, None; B. Siesky, None; E. Brizendine, None; D. Sines, None; C.W. Yung, None; O. Geyer, None; H.J. Garzozi, None.
  • Footnotes
    Support  Research to Prevent Blindness, Inc., New York.
Investigative Ophthalmology & Visual Science May 2006, Vol.47, 2170. doi:
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      E. Rechtman, A. Harris, T.A. Ciulla, R.P. Danis, B. Siesky, E. Brizendine, D. Sines, C.W. Yung, O. Geyer, H.J. Garzozi; The Relationship Between Retrobulbar and Choroidal Hemodynamics in Non–Neovascular Age–Related Macular Degeneration . Invest. Ophthalmol. Vis. Sci. 2006;47(13):2170.

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Abstract

Purpose: : To evaluate the relationship between retrobulbar and choroidal hemodynamics in non–neovascular age–related macular degeneration (AMD)

Methods: : In a prospective study, 13 non–neovascular AMD patients were assessed by both color Doppler imaging (CDI) and scanning laser ophthalmoscope indocyanine green (SLO ICG) angiography. CDI was used to measure peak–systolic and end–diastolic velocity (PSV and EDV) (from which the resistance index (RI) was calculated) in the ophthalmic, central retinal, and posterior ciliary arteries. SLO ICG angiograms were analyzed by area dilution analysis (ADA), which yields fluorescence intensity parameters within perifoveal and temporal peripapillary regions. All CDI parameters were correlated with all SLO ICG ADA measurements. In addition, CDI and SLO ICG parameters were correlated with visual acuity and axial length. Pearson correlation was used to compare CDI parameters (PSV, EDV, RI) with ICG measures (duration, 10% and 63% filling times) and A–scan and visual acuity with CDI and ICG parameters. P values < 0.05 were considered statistically significant.

Results: : Significant positive correlations were found between the posterior ciliary arteries RI and SLO ICG ADA fluorescence duration (peripapillary: p < 0.05, r = 0.78; perifoveal: p < 0.05, r = 0.72). There were moderate correlations between the ophthalmic artery CDI RI and SLO ICG 63% filling time parameters (peripapillary: NS; perifoveal: p < 0.05, r = 0.57). No correlations were found between central retinal artery CDI RI and SLO ICG parameters. Also, CDI and SLO ICG parameters did not correlate with the patients’ visual acuity or with the axial length.

Conclusions: : SLO ICG ADA duration correlates with posterior ciliary arteries RI and may help in AMD, as well as in other ocular disease, vascular assessment.

Keywords: age-related macular degeneration • retina • imaging/image analysis: clinical 
© 2006, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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