May 2006
Volume 47, Issue 13
ARVO Annual Meeting Abstract  |   May 2006
A Saline Challenge of a Silver–Impregnated Lens Case
Author Affiliations & Notes
  • M.L. Ajello
    CIBA Vision Corporation, Duluth, GA
    Lens Care Development,
  • M. George
    CIBA Vision Corporation, Duluth, GA
    Lens Care Development,
  • M. Mowrey–Mckee
    CIBA Vision Corporation, Duluth, GA
    Toxicology & Microbiology,
  • Footnotes
    Commercial Relationships  M.L. Ajello, CIBA Vision Corporation, E; M. George, CIBA Vision Corporation, E; M. Mowrey–Mckee, CIBA Vision Corporation, E.
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science May 2006, Vol.47, 2411. doi:
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      M.L. Ajello, M. George, M. Mowrey–Mckee; A Saline Challenge of a Silver–Impregnated Lens Case . Invest. Ophthalmol. Vis. Sci. 2006;47(13):2411.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : Lens case contamination is a well–documented occurrence for patients who wear contact lenses despite the efficacy of currently marketed lens disinfectants. Several microorganisms have a propensity to attach to surfaces and may become more tolerant of disinfection than planktonic (free–swimming) cells. Additionally, non–compliance with disinfection regimens occasionally occurs wherein patients store their lenses in saline or in tap water. In these circumstances, the ability of the lens case to inhibit contamination on its own takes on additional importance. This study examined the efficacy of the PRO–GUARD silver–impregnated lens case in the absence of disinfecting solution against saline suspensions of known lens case contaminants. A low inoculum level was employed to more closely mimic real world exposure conditions. Performance of the PRO–GUARD case versus currently available lens cases was assessed.

Methods: : Lens case bowls were challenged with 103 microorganism suspensions of Pseudomonas, Serratia, and Citrobacter strains. After twenty–four hours incubation at room temperature, aliquots of inocula were removed and spread plated onto appropriate growth media. Surviving colonies were counted and microorganism log drop values from initial challenge inocula were determined.

Results: : The PRO–GUARD case demonstrated kill of Pseudomonas and Citrobacter after 24 hours exposure at room temperature. Bausch and Lomb® (ReNu®) and Complete® cases showed replication of these microorganisms (growth) after 24 hours. Opti–Free® cases demonstrated growth of Pseudomonas and stasis against Citrobacter. All lens cases demonstrated stasis against Serratia though the PRO–GUARD cases had a statistically significantly lower number of recoverable colonies than competitor cases.

Conclusions: : The PRO–GUARD silver–impregnated lens case was developed in an effort to provide enhanced safety for patients by reducing potential lens case contamination between and after contact lens disinfection. In all challenges, the PRO–GUARD case had a statistically significantly lower number of recovered microorganisms than all competitor cases and shows promise as an added benefit to the contact lens care system.

Keywords: contact lens • Pseudomonas 

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