May 2006
Volume 47, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2006
Duration of Binocular Decorrelation Predicts the Severity of Nasotemporal Pursuit Asymmetries in Strabismic Macaque Monkeys
Author Affiliations & Notes
  • A. Hasany
    Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, ON, Canada
  • A.M. Wong
    Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, ON, Canada
    Department of Ophthalmology and Visual Sciences, Washington University in St. Louis, St. Louis, MO
  • P. Foeller
    Department of Ophthalmology and Visual Sciences, Washington University in St. Louis, St. Louis, MO
  • D. Bradley
    Yerkes Regional Primate Research Center, Atlanta, GA
  • L. Tychsen
    Department of Ophthalmology and Visual Sciences, Washington University in St. Louis, St. Louis, MO
  • Footnotes
    Commercial Relationships  A. Hasany, None; A.M. Wong, None; P. Foeller, None; D. Bradley, None; L. Tychsen, None.
  • Footnotes
    Support  NIH Grant EY 10214–08
Investigative Ophthalmology & Visual Science May 2006, Vol.47, 2452. doi:
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      A. Hasany, A.M. Wong, P. Foeller, D. Bradley, L. Tychsen; Duration of Binocular Decorrelation Predicts the Severity of Nasotemporal Pursuit Asymmetries in Strabismic Macaque Monkeys . Invest. Ophthalmol. Vis. Sci. 2006;47(13):2452.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : Infantile esotropia is associated with nasotemporal asymmetries of pursuit during monocular viewing. The purpose of this study was to determine how the duration of binocular decorrelation – which can be strictly controlled in primates – influences directional pursuit asymmetries.

Methods: : Optical strabismus was created in 7 infant macaques by fitting them with prism goggles on day 1 of life. The goggles were removed after 3 wks (n=2), 3 mos (n=1) or 6 mos (n=2), emulating surgical repair of strabismus in humans at 3 mos, 12 mos, and 24 mos of age, respectively. Two control monkeys wore plano lenses. After the goggles were removed, horizontal pursuit was recorded using search coils, evoked by "step–ramp" target motion. A nasal bias index (NBI) was calculated as (Sn–St )/(Sn+St), where Sn is nasally–directed and St is temporally–directed mean eye speed.

Results: : Each animal in the 3 and 6–mos duration groups showed asymmetries of pursuit at both target speeds. The longer the duration, the more severe the asymmetry: for 15 deg/s targets, the NBI in the 6 mos group was 5 times greater than that in the 3 mos group, and 30 times greater than that in the 3 wk group (ANOVA, p=0.03). For 30 deg/s target motion, the NBI in the 6 mos–duration group was 4 times greater than that in the 3 mos group, and 12 times greater than that in the 3 wk group (ANOVA, p=0.05). Controls had symmetric pursuit.

Conclusions: : Early correction of strabismus (i.e. elimination of binocular decorrelation) prevents maldevelopment of the pursuit system. These findings indicate that early correction of infantile strabismus is beneficial for brain development.

Keywords: strabismus • strabismus: treatment 
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