May 2006
Volume 47, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2006
Topical Ibopamine In The Treatment Of Chronic Ocular Hypotony Due To Vitreoretinal Surgery, Uveitis Or Penetrating Trauma
L. Ugahary; E. Ganteris– Gerritsen; M. Veckeneer; A.C. Cohen; J. Jansen; P.G. H. Mulder; J.C. van Meurs
Author Affiliations & Notes
  • L. Ugahary
    Ophthalmology, Oogziekenhuis Rotterdam, Rotterdam, The Netherlands
  • E. Ganteris– Gerritsen
    Ophthalmology, Oogziekenhuis Rotterdam, Rotterdam, The Netherlands
  • M. Veckeneer
    Ophthalmology, Oogziekenhuis Rotterdam, Rotterdam, The Netherlands
  • A.C. Cohen
    Centre for Human Drug Research, Leiden, The Netherlands
  • J. Jansen
    Westblaak Pharmacy, Rotterdam, The Netherlands
  • P.G. H. Mulder
    Department of Epidemiology & Biostatistics, Erasmus University Medical Centre Rotterdam, Rotterdam, The Netherlands
  • J.C. van Meurs
    Ophthalmology, Oogziekenhuis Rotterdam, Rotterdam, The Netherlands
  • Footnotes
    Commercial Relationships  L. Ugahary, None; E. Ganteris– Gerritsen, None; M. Veckeneer, None; A.C. Cohen, None; J. Jansen, None; P.G.H. Mulder, None; J.C. van Meurs, None.
  • Footnotes
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Investigative Ophthalmology & Visual Science May 2006, Vol.47, 2610. doi:
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      L. Ugahary, E. Ganteris– Gerritsen, M. Veckeneer, A.C. Cohen, J. Jansen, P.G. H. Mulder, J.C. van Meurs; Topical Ibopamine In The Treatment Of Chronic Ocular Hypotony Due To Vitreoretinal Surgery, Uveitis Or Penetrating Trauma . Invest. Ophthalmol. Vis. Sci. 2006;47(13):2610.

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Abstract

Purpose: : To study whether topical ibopamine effectively increases the intra–ocular pressure in patients with ocular hypotony after vitreoretinal surgery, uveitis or penetrating trauma

Methods: : In ten patients with ocular hypotony, a 2% ibopamine or placebo eye drop was administered at 8 AM and 12 AM and frequent applanation tonometry was performed during ten hours on two days two weeks apart

Results: : The mean IOP integral after administration of ibopamine was 2.4 mmHg higher (95% CI for median difference in AUC over 480 minutes (p=0.010)) compared to placebo

Conclusions: : The results of the study show that a ibopamine 2% eye drop twice a day may increase the IOP for a period of over eight hours in patients with hypotony

Keywords: intraocular pressure • drug toxicity/drug effects • clinical (human) or epidemiologic studies: treatment/prevention assessment/controlled clinical trials 
© 2006, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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