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J.D. Perry, M. Taban; Plasma Leptin Levels in Patients With Floppy Eyelid Syndrome . Invest. Ophthalmol. Vis. Sci. 2006;47(13):2625.
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To determine the range of plasma leptin levels in patients with floppy eyelid syndrome.
Retrospective chart review of eleven patients with floppy eyelid syndrome who underwent plasma leptin level testing. Charts of all patients with floppy eyelid syndrome who underwent plasma leptin level testing during the period from January 2000 through January 2005 were reveiwed. Charts were reviewed for patient age, gender, plasma leptin level, presence or absence of obstructive sleep apnea, treatement of obstructive sleep apnea, and body mass index.
Plasma leptin levels were elevated in 7/11 patients with floppy eyelid syndrome (64%). Mean plasma leptin level was 61.4 ng/ml (range, 5–180 ng/ml) compared to the laboratory normal range of 1–35 ng/ml for males and 3.6–72.4 ng/ml for females. Average body mass index was 37.4. Four of five patients with a known history of obstructive sleep apnea received CPAP treatment, and plasma leptin levels averaged 110.0 ng/ml in this group. All patients with elevated leptin levels had a high body mass index.
Plasma leptin levels correlate positively with a high body mass index in patients with floppy eyelid syndrome. To our knowlege, this association has not been previously described. This association may help elucidate the mechanism underlying floppy eyelid syndrome.
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