Reproducibility of Retinal Layer Thickness Measurements Using a Novel Macular Segmentation Software

Abstract

 

Purpose:

 

To investigate the reproducibility of retinal layer thickness measurements using a novel macular segmentation software¹ applied to optical coherence tomography (OCT) macular scans of healthy and glaucomatous eyes.

 

Methods:

 

Fifteen eyes of healthy subjects (15 subjects) had undilated StratusOCT fast macular scans performed 3 consecutive times in 3 visits. Eight eyes of glaucoma subjects (8 subjects) had 2 consecutive scans in 2 visits. Macular segmentation software automatically defined the overall retinal thickness (RT) and 4 retinal layers: macular nerve fiber layer (mNFL), inner retinal complex (IRC; retinal ganglion cell layer+inner plexiform and nuclear layers), outer plexiform layer (OPL), and outer retinal complex (ORC; outer nuclear layer+photoreceptor layer). Intravisit and intervisit reproducibility of measurements in both healthy and glaucomatous eyes were evaluated by the calculation of the intraclass correlation coefficient (ICC) for each parameter.

 

Results:

 

The mean visual field mean deviation (MD) was –0.15 ± 1.05 dB for the healthy group and –3.56 ± 4.52 dB for the glaucoma group. Intraclass Correlation Coeffectient Table:  

 

Conclusions:

 

Macular segmentation analysis provided reproducible measurements for most of the parameters.

 

References:

 

¹Ishikawa H, et al. IOVS 2005; 46:2012–7.

 

Keywords: imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound)