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W.D. Dilworth, T. Mumcuoglu, E. Wu, G. Wollstein, H. Ishikawa, L. Kagemann, M. Gabriele, R.J. Noecker, J.S. Schuman; Reproducibility of Retinal Layer Thickness Measurements Using a Novel Macular Segmentation Software . Invest. Ophthalmol. Vis. Sci. 2006;47(13):2633.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate the reproducibility of retinal layer thickness measurements using a novel macular segmentation software1 applied to optical coherence tomography (OCT) macular scans of healthy and glaucomatous eyes.
Fifteen eyes of healthy subjects (15 subjects) had undilated StratusOCT fast macular scans performed 3 consecutive times in 3 visits. Eight eyes of glaucoma subjects (8 subjects) had 2 consecutive scans in 2 visits. Macular segmentation software automatically defined the overall retinal thickness (RT) and 4 retinal layers: macular nerve fiber layer (mNFL), inner retinal complex (IRC; retinal ganglion cell layer+inner plexiform and nuclear layers), outer plexiform layer (OPL), and outer retinal complex (ORC; outer nuclear layer+photoreceptor layer). Intravisit and intervisit reproducibility of measurements in both healthy and glaucomatous eyes were evaluated by the calculation of the intraclass correlation coefficient (ICC) for each parameter.
The mean visual field mean deviation (MD) was –0.15 ± 1.05 dB for the healthy group and –3.56 ± 4.52 dB for the glaucoma group. Intraclass Correlation Coeffectient Table:
Macular segmentation analysis provided reproducible measurements for most of the parameters.
1Ishikawa H, et al. IOVS 2005; 46:2012–7.
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