May 2006
Volume 47, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2006
Use of Topical Human Amniotic Fluid in the Treatment of Acute Alkali Burns of the Eye
A. Pirouzmanesh; S.P. Herretes; O. Suwan–Apichon; J.M. G. Reyes; M. Cano; P. Gehlbach; E. Duh; E. Gurewitsch; A. Behrens
Author Affiliations & Notes
  • A. Pirouzmanesh
    Department of Ophthalmology, University of California, Irvine, Irvine, CA
    Wilmer Eye Institute,
    Johns Hopkins University School of Medicine, Baltimore, MD
  • S.P. Herretes
    Wilmer Eye Institute,
    Johns Hopkins University School of Medicine, Baltimore, MD
  • O. Suwan–Apichon
    Wilmer Eye Institute,
    Johns Hopkins University School of Medicine, Baltimore, MD
  • J.M. G. Reyes
    Wilmer Eye Institute,
    Johns Hopkins University School of Medicine, Baltimore, MD
  • M. Cano
    Wilmer Eye Institute,
    Johns Hopkins University School of Medicine, Baltimore, MD
  • P. Gehlbach
    Wilmer Eye Institute,
    Johns Hopkins University School of Medicine, Baltimore, MD
  • E. Duh
    Wilmer Eye Institute,
    Johns Hopkins University School of Medicine, Baltimore, MD
  • E. Gurewitsch
    Department of Obstetrics and Gynecology,
    Johns Hopkins University School of Medicine, Baltimore, MD
  • A. Behrens
    Wilmer Eye Institute,
    Johns Hopkins University School of Medicine, Baltimore, MD
  • Footnotes
    Commercial Relationships  A. Pirouzmanesh, None; S.P. Herretes, None; O. Suwan–Apichon, None; J.M.G. Reyes, None; M. Cano, None; P. Gehlbach, None; E. Duh, None; E. Gurewitsch, None; A. Behrens, None.
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science May 2006, Vol.47, 2722. doi:
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      A. Pirouzmanesh, S.P. Herretes, O. Suwan–Apichon, J.M. G. Reyes, M. Cano, P. Gehlbach, E. Duh, E. Gurewitsch, A. Behrens; Use of Topical Human Amniotic Fluid in the Treatment of Acute Alkali Burns of the Eye . Invest. Ophthalmol. Vis. Sci. 2006;47(13):2722.

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Abstract

Purpose: : To evaluate the efficacy of topical human amniotic fluid (HAF) in the treatment of acute alkali burns.

Methods: : An alkali burn with a drop of 2 µl NaOH 0.15 M was attempted in 30 C57BL/6 mice. Animals were divided into three treatment groups: saline, pre–term HAF, term HAF. Epithelial defect/degree of ocular damage were assessed by blinded observers.

Results: : Epithelial defect at day 4 was: 25.13 ± 19.98%; 10.42 ± 5.63% and 7.03 ± 2.45%, respectively (P < .028). Degree of ocular damage at day 14 was: 4.13 ± 2.32; 2.10 ± 1.31, and 2.04 ± 1.37, respectively (P < .036).

Conclusions: : Topical HAF was significantly more effective than saline in promoting re–epithelialization and reducing ocular damage in this animal model.

Keywords: wound healing • cornea: epithelium 
© 2006, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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