May 2006
Volume 47, Issue 13
ARVO Annual Meeting Abstract  |   May 2006
Comparison of Rates of Epithelial Wound Healing With Gatifloxacin and Moxifloxacin Following Penetrating Keratoplasty
Author Affiliations & Notes
  • S.E. Pascucci
    Ophthalmology, Florida, Ft, FL
  • J. Wittpenn
    Private Practice, Stony Brook, NY
  • S. Silverstein
    Private Practice, Kansas City, MO
  • D. Katsev
    Private Practice, Santa Barbara, CA
  • S. Kaufman
    Private Practice, Grosse Pointe, MI
  • Footnotes
    Commercial Relationships  S.E. Pascucci, Allergan, F; J. Wittpenn, Allergan, C; S. Silverstein, None; D. Katsev, None; S. Kaufman, None.
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science May 2006, Vol.47, 2749. doi:
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      S.E. Pascucci, J. Wittpenn, S. Silverstein, D. Katsev, S. Kaufman; Comparison of Rates of Epithelial Wound Healing With Gatifloxacin and Moxifloxacin Following Penetrating Keratoplasty . Invest. Ophthalmol. Vis. Sci. 2006;47(13):2749.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : To evaluate the effect of gatifloxacin 0.3% (Zymar, Allergan) and moxifloxacin 0.5% (Vigamox, Alcon) ophthalmic solutions on the rate of epithelial wound healing following penetrating keratoplasty.

Methods: : Randomized, investigator–masked, multi–center clinical trial. Starting on the day of surgery, patients (n= 60) scheduled to undergo corneal transplantation instilled either gatifloxacin or moxifloxacin QID for 2 weeks or until the investigator determined that the epithelium healed. Study visits were scheduled for postoperative days 1, 4, 7, 10, 14, and 21.

Results: : In this interim analysis of 27 patients, eyes treated with gatifloxacin had substantially smaller epithelial defects at day 4 than eyes treated with moxifloxacin (mean defect size of 3.7 mm with gatifloxacin vs 7.6 mm with moxifloxacin, P=.339). In addition, 57% of gatifloxacin–treated eyes had completely healed at day 4, compared with 50% of moxifloxacin–treated eyes. By day 7, 100% of gatifloxacin–treated eyes had completed healed, compared with 83% of moxifloxacin–treated eyes. Healing was delayed in 1 moxifloxacin–treated eye until day 21.

Conclusions: : The findings of this preliminary analysis suggest that gatifloxacin delays wound healing less than moxifloxacin following penetrating keratoplasty.

Keywords: wound healing • antibiotics/antifungals/antiparasitics 

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