May 2006
Volume 47, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2006
A Relationship Between Altered in vivo Retinal Microvascular Blood Flow and Leukocyte Rigidity in HIV–Infected Individuals
H. Dadgostar; G.N. Holland; X. Huang; A. Tufail; A. Kim; T. Fisher; W.G. Cumberland; H.J. Meiselman; A. Benjamin; D.–U. Bartsch
Author Affiliations & Notes
  • H. Dadgostar
    Ophthalmology, Jules Stein Eye Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA
  • G.N. Holland
    Ophthalmology, Jules Stein Eye Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA
  • X. Huang
    Biostatistics, UCLA School of Public Health, Los Angeles, CA
  • A. Tufail
    Ophthalmology, Jules Stein Eye Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA
  • A. Kim
    Ophthalmology, Jules Stein Eye Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA
  • T. Fisher
    Physiology and Biophysics, USC School of Medicine, Los Angeles, CA
  • W.G. Cumberland
    Biostatistics, UCLA School of Public Health, Los Angeles, CA
  • H.J. Meiselman
    Physiology and Biophysics, USC School of Medicine, Los Angeles, CA
  • A. Benjamin
    Ophthalmology, Jules Stein Eye Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA
  • D.–U. Bartsch
    Ophthalmology, Shiley Eye Center, UCSD, La Jolla, CA
  • Footnotes
    Commercial Relationships  H. Dadgostar, None; G.N. Holland, None; X. Huang, None; A. Tufail, None; A. Kim, None; T. Fisher, None; W.G. Cumberland, None; H.J. Meiselman, None; A. Benjamin, None; D. Bartsch, Heidelberg Engineering, R.
  • Footnotes
    Support  Research to Prevent Blindness, Inc.
Investigative Ophthalmology & Visual Science May 2006, Vol.47, 3060. doi:
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      H. Dadgostar, G.N. Holland, X. Huang, A. Tufail, A. Kim, T. Fisher, W.G. Cumberland, H.J. Meiselman, A. Benjamin, D.–U. Bartsch; A Relationship Between Altered in vivo Retinal Microvascular Blood Flow and Leukocyte Rigidity in HIV–Infected Individuals . Invest. Ophthalmol. Vis. Sci. 2006;47(13):3060.

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Abstract

Purpose: : To evaluate retinal microvascular blood flow in individuals with human immunodeficiency virus (HIV) infection using scanning laser Doppler flowmetry (SLDF) and to correlate abnormal flow with multiple systemic hemorheologic indices.

Methods: : Using the Heidelberg Retina Flowmeter and SLDF software retinal blood flow data was acquired from HIV–infected individuals (n = 24) and HIV–negative controls (n = 16). Separate scans represented each of six retinal regions: nasal peripapillary; macular; and superior, nasal, inferior and temporal periphery. RBC aggregation (assessed by Myrenne aggregometry, zeta sedimentation ratio [ZSR; a hematocrit–independent sedimentation rate], and serum fibrinogen level), plasma viscosity and WBC rigidity (measured using a cell transit analyzer) were compared to flow.

Results: : Topographic blood flow analysis revealed significantly faster flow in the periphery (superior, nasal, inferior, temporal) than in the central retina (nasal peripapillary, macular) with the most rapid flow observed in the temporal periphery (p<0.0001) for both HIV–infected and HIV–negative subjects. Microvascular flow in the central retina was significantly slower in HIV–infected subjects than in controls (p<0.0001). Among HIV–infected individuals, there was a significant negative correlation between macular blood flow and WBC transit time (r = –0.59, p = 0.0024) and a weaker negative correlation between macular blood flow and ZSR (r = –0.44, p = 0.0314).

Conclusions: : Using a non–invasive in vivo measure, central retinal microvascular flow is shown to be reduced in HIV–infected individuals. Out of multiple potential influences on flow, WBC rigidity appears to play the strongest role in this blood flow reduction. Altered microvascular blood flow may contribute to retinal disease among HIV–infected individuals.

Keywords: AIDS/HIV • clinical laboratory testing • retina 
© 2006, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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