May 2006
Volume 47, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2006
Safety and Tolerance of Bevacizumab Injection in Rabbit Anterior Chamber
D. Moreno–Paramo; A. Perez – Reguera; A. Meza – de Regil; M. Abraham; M. Parrochia; G. Alvarez–Rivera; O. Ustariz–González; J. Carmona; E. Romo; H. Quiroz – Mercado
Author Affiliations & Notes
  • D. Moreno–Paramo
    Retina, APEC, Mexico, Mexico
  • A. Perez – Reguera
    Retina, APEC, Mexico, Mexico
  • A. Meza – de Regil
    Retina, APEC, Mexico, Mexico
  • M. Abraham
    Retina, APEC, Mexico, Mexico
  • M. Parrochia
    Retina, APEC, Mexico, Mexico
  • G. Alvarez–Rivera
    Retina, APEC, Mexico, Mexico
  • O. Ustariz–González
    Retina, APEC, Mexico, Mexico
  • J. Carmona
    Retina, APEC, Mexico, Mexico
  • E. Romo
    Retina, APEC, Mexico, Mexico
  • H. Quiroz – Mercado
    Retina, APEC, Mexico, Mexico
  • Footnotes
    Commercial Relationships  D. Moreno–Paramo, None; A. Perez – Reguera, None; A. Meza – de Regil, None; M. Abraham, None; M. Parrochia, None; G. Alvarez–Rivera, None; O. Ustariz–González, None; J. Carmona, None; E. Romo, None; H. Quiroz – Mercado, None.
  • Footnotes
    Support  Riarronte Foundation
Investigative Ophthalmology & Visual Science May 2006, Vol.47, 3236. doi:
  • Views
  • Share
  • Tools
    • Alerts
      User Alerts
      You are adding an alert for:
      Safety and Tolerance of Bevacizumab Injection in Rabbit Anterior Chamber
      You will receive an email whenever this article is corrected, updated, or cited in the literature. You can manage this and all other alerts in My Account
      The alert will be sent to:
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation
      Citation

      D. Moreno–Paramo, A. Perez – Reguera, A. Meza – de Regil, M. Abraham, M. Parrochia, G. Alvarez–Rivera, O. Ustariz–González, J. Carmona, E. Romo, H. Quiroz – Mercado; Safety and Tolerance of Bevacizumab Injection in Rabbit Anterior Chamber . Invest. Ophthalmol. Vis. Sci. 2006;47(13):3236.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

      ×
    • Get Permissions
  • Supplements
Abstract

Purpose: : To report the effects (safety and tolerance) of Bevacizumab injection (Avastin, Genetec. Inc) in rabbits anterior chamber and report changes of endothelial cells.

Methods: : Four eyes of four rabbits were injected with Bevacizumab via corneal at different concentrations (0.1 and 0.2 ml); all of them presented Bevacizumab in the anterior chamber immediately after the procedure. The eyes were evaluated with specular microscopy at the first and 7th day after injection.

Results: : All rabbits maintained corneal transparency in every control. Specular microscopy showed no change in the count of endothelial cell and in cell form.

Conclusions: : Bevacizumab does not present a toxic effect over the corneal endothelial cells.

Keywords: growth factors/growth factor receptors • retinal neovascularization • cornea: endothelium 
© 2006, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×
This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy.Accept