May 2006
Volume 47, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2006
Visual Field Quality Control in the Ocular Hypertension Treatment Study (OHTS) and the Optic Neuritis Treatment Trial (ONTT)
Author Affiliations & Notes
  • J.L. Keltner
    Department of Ophthalmology and Visual Science, University of California, Davis, Sacramento, CA
  • C.A. Johnson
    Discoveries in Sight, Devers Eye Institution, Portland, OR
  • K.E. Cello
    Department of Ophthalmology and Visual Science, University of California, Davis, Sacramento, CA
  • J. Fan
    Department of Mathematics and Statistics, San Diego State University, San Diego, CA
  • R.A. Levine
    Department of Mathematics and Statistics, San Diego State University, San Diego, CA
  • S.E. Bandermann
    Department of Ophthalmology and Visual Science, University of California, Davis, Sacramento, CA
  • M.A. Kass
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO
  • M.O. Gordon
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO
  • R.W. Beck
    Jaeb Center for Health Research, Tampa, FL
  • Ocular Hypertension Treatment Study Group
    Department of Ophthalmology and Visual Science, University of California, Davis, Sacramento, CA
  • Footnotes
    Commercial Relationships  J.L. Keltner, None; C.A. Johnson, None; K.E. Cello, None; J. Fan, None; R.A. Levine, None; S.E. Bandermann, None; M.A. Kass, None; M.O. Gordon, None; R.W. Beck, None.
  • Footnotes
    Support  EY09307, EY09341
Investigative Ophthalmology & Visual Science May 2006, Vol.47, 3394. doi:
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      J.L. Keltner, C.A. Johnson, K.E. Cello, J. Fan, R.A. Levine, S.E. Bandermann, M.A. Kass, M.O. Gordon, R.W. Beck, Ocular Hypertension Treatment Study Group; Visual Field Quality Control in the Ocular Hypertension Treatment Study (OHTS) and the Optic Neuritis Treatment Trial (ONTT) . Invest. Ophthalmol. Vis. Sci. 2006;47(13):3394.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To compare visual field quality control (QC) data in the Ocular Hypertension Treatment Study (OHTS) and in the 10–year Optic Neuritis Treatment Trial (ONTT) follow–up study.

Methods: : We evaluated 46,777 visual fields from 1,618 OHTS participants and 722 visual fields from 270 ONTT participants. The visual field QC protocol in OHTS included training, certification, and on–going feedback to technicians on each visual field as well as quarterly reports on visual field quality. The visual field QC protocol in ONTT included training and certification, but lacked on–going feedback on each visual field and repeated visual field testing of participants over time. An ancillary study was also conducted in the ONTT using the SITA (Swedish Interactive Thresholding Algorithm) Fast Central 24–2 test strategy. Five clinical centers participated in this ancillary study.

Results: : For OHTS, 2.4% (1,136 of 46,777) of the visual fields were unreliable and 0.23% (107 of 46,777) had incorrect test parameters. For the ONTT 10–year follow up study, 6% (43/ 722) of the visual fields were unreliable and 19% (134/722) had incorrect test parameters. Visual field defects attributed to testing artifacts contributed to approximately 1% (483/ 46,777) of the OHTS total visual fields and 1% (7/722) of the ONTT total visual fields. There were 6 major QC differences between study parameters used in OHTS and ONTT which included different visual field entry, shipping and testing requirements, certification procedures, QC reporting, and error notification.

Conclusions: : Reliability was high in both studies. Ongoing quality control, along with technician feedback/instruction, helps to reduce unreliability and incorrect test parameters in visual field data.

Keywords: visual fields • perimetry • neuro-ophthalmology: optic nerve 
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