May 2006
Volume 47, Issue 13
ARVO Annual Meeting Abstract  |   May 2006
Comparison Of The Risk Estimates For Converting To Glaucoma With Two Published Risk Calculators
Author Affiliations & Notes
  • G.A. Cioffi
    Ophthal–Discoveries, Devers, Portland, OR
  • S.L. Mansberger
    Ophthal–Discoveries, Devers, Portland, OR
  • Footnotes
    Commercial Relationships  G.A. Cioffi, None; S.L. Mansberger, None.
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science May 2006, Vol.47, 3413. doi:
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      G.A. Cioffi, S.L. Mansberger; Comparison Of The Risk Estimates For Converting To Glaucoma With Two Published Risk Calculators . Invest. Ophthalmol. Vis. Sci. 2006;47(13):3413.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : To compare the risk estimates of the Devers Ocular Hypertension to Glaucoma Risk Calculator (Devers) to a separate calculator developed by University of California, San Diego (UCSD).

Methods: : We created a database of 1000 ocular hypertensive patients representative of the Ocular Hypertension Treatment Study (OHTS) patients. Each patient received 6 computer–generated random numbers to randomly create age, diabetes, intraocular pressure, corneal thickness, pattern standard deviation (PSD), and cup–to–disc ratio(C/D). We recreated any random number result outside of the OHTS range and determined the risk estimates for these predictive variables using the Devers and UCSD calculators.

Results: : Average age was 60.5 +/–11.5; diabetes was 12%; IOP was 27.5 +/– 2.5; corneal thickness was 563 +/– 62; PSD was 1.3 +/– 0.8; and C/D was 0.4 +/– 0.2 for the database. The Devers calculator had a lower estimate of risk. The overall mean difference between the Devers and UCSD calculator risk estimates was 1.2% +/– 3.9 (range 0.0 to 22.8%). The correlation between risk estimates was high (Rsq=0.99, p<0.001).

Conclusions: : The Devers and UCSD calculator have similar estimates of risk. We need comparisons of the calculators in a clinical database to determine the accuracy of the estimates for converting from ocular hypertension to glaucoma.

Keywords: clinical (human) or epidemiologic studies: risk factor assessment • clinical (human) or epidemiologic studies: biostatistics/epidemiology methodology 

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