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S.C. Ume, M. Sehi, W.J. Feuer, D.S. Greenfield, Advanced Imaging in Glaucoma Study Group; Structural Assessments Using Scanning Laser Polarimetry with Enhanced Corneal Compensation, Optical Coherence Tomography, and Heidelberg Retina Tomography in Normal and Glaucomatous Eyes . Invest. Ophthalmol. Vis. Sci. 2006;47(13):3641.
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© ARVO (1962-2015); The Authors (2016-present)
To examine the association between scanning laser polarimetry (SLP) using enhanced corneal compensation (ECC) and variable corneal compensation (VCC) with optical coherence tomography (OCT) and Heidelberg retina tomography (HRT).
Sixty–four perimetric glaucoma (PG) patients (age 62.8±8.4 years) and 101 normal (N) volunteers (age 54.4±10.4 years) were included from four clinical sites. One randomly selected eye was enrolled. Standard automated perimetry (SAP), SLP, OCT and HRT were performed on all subjects. Abnormal SAP was defined as glaucoma hemifield test outside normal limits and pattern standard deviation of p<5%. Exclusion criteria were visual acuity < 20/40, diseases other than glaucoma and unreliable SAP. Pearson correlation coefficients were calculated and compared using a test of homogeneity among paired correlation coefficients.
Average SAP mean deviation was –0.5±1.7 in normal and –3.8±3.6 in PG. TSNIT average using ECC and VCC were significantly (all p<0.001) correlated with OCT–derived optic disc rim volume (r = 0.62 vs 0.60), average retinal nerve fiber layer (RNFL) thickness (r = 0.76 vs 0.72), superior (r = 0.67 vs 0.65) and inferior RNFL thickness (r = 0.72 vs 0.73). TSNIT average using ECC and VCC were significantly (p = 0.001 to 0.03) correlated with HRT–derived cup–to–disc area ratio (r = –0.48 vs –0.50), rim area (r = 0.21 vs 0.16) and rim volume (r =0.29 vs 0.28).Compared with VCC, TSNIT average using ECC had a significantly (p = 0.008) greater correlation with OCT average RNFL thickness.
SLP parameters using both ECC and VCC were strongly correlated with structural assessments using OCT and HRT in this population.
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