May 2006
Volume 47, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2006
Effect of Intraocular Pressure Lowering on Optical Coherence Tomography Measurement of Retinal Nerve Fiber Layer Thickness
Author Affiliations & Notes
  • P.T. Chang
    Ophthalmology, Baylor College of Medicine, Houston, TX
  • P.W. Park
    Harvard Eye Associates, Laguna Hills, CA
  • D.L. Budenz
    Ophthalmology, Bascom Palmer Eye Institute, Miami, FL
  • N. Sekhon
    Ophthalmology, Bascom Palmer Eye Institute, Miami, FL
  • D.R. Anderson
    Ophthalmology, Bascom Palmer Eye Institute, Miami, FL
  • Footnotes
    Commercial Relationships  P.T. Chang, None; P.W. Park, None; D.L. Budenz, Carl Zeiss, Inc., F; Carl Zeiss, Inc., R; N. Sekhon, None; D.R. Anderson, Carl Zeiss, Inc., F.
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science May 2006, Vol.47, 3649. doi:
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      P.T. Chang, P.W. Park, D.L. Budenz, N. Sekhon, D.R. Anderson; Effect of Intraocular Pressure Lowering on Optical Coherence Tomography Measurement of Retinal Nerve Fiber Layer Thickness . Invest. Ophthalmol. Vis. Sci. 2006;47(13):3649.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To study the effect of intraocular pressure (IOP) lowering on the peripapillary retinal nerve fiber layer (PRNFL) thickness as determined by the newest generation of optical coherence tomography (OCT; Stratus OCT, Carl Zeiss, Inc.)

Methods: : OCT was performed prior to intervention to lower IOP (0 to 38 days before; mean ± standard deviation [SD], 9.8 ± 9.3 days) and after the intervention (32 to 74 days; 46.8 ± 11.2 days) to measure PRNFL thickness. The intervention involved trabeculectomy with antimetabolite, Baerveldt aqueous shunt implantation, or medical treatment.

Results: : IOP decreased from 31.5 ± 8.2 mm Hg to 18.8 ± 9.4 mm Hg (mean ± SD) with the intervention. There was no significant change in the overall mean PRNFL thickness associated with the lowering of IOP (p = 0.65). Quadrant analysis did not show a significant change in PRNFL thickness of any of the four quadrants (p ≥ 0.30). No significant correlation was found between extent of IOP reduction and any of the changes in OCT parameters or % changes in OCT parameters with or without adjusting for pre–operative OCT measurements (p–values ranged from 0.33 to 0.99).

Conclusions: : No significant change in PRNFL thickness was associated with the lowering of IOP via medical or surgical therapy.

Keywords: imaging/image analysis: clinical • intraocular pressure • nerve fiber layer 
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