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C. Brue, F. Luciani, S. Celani, M. Manenti, P. Neri, G. Finicelli, C. Mariotti, A. Giovannini; Resonance Raman Spectroscopic Measurement of Macular Carotenoids in Normal and Myopic Eyes of Young European Subjects . Invest. Ophthalmol. Vis. Sci. 2006;47(13):3796.
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Light–adsorbing macular carotenoids (MCs), i.e. lutein and zeaxanthin, are efficient free radical scavengers in the human retina and might play a role in the pathogenesis of major myopia–related diseases, such as choroidal neovascularisation. The present study aimed at verifying whether MCs levels correlate with the myopia grade.
Sixty–three European 20–31 years old (mean age 26.3 years) healthy subjects were divided in four matched groups: i) control (negative for myopia, n=25); and ii) mild (< 3 D, n=12), iii) medium (3–6 D, n=14) and, iv) high (> 6 D, n=12) myopia. The levels of MCs were measured by a resonance Raman spectroscope in all of the subjects. Both the eyes of each subject were monitored and triplicate measurements were performed at each time. Moreover, pupil dilatation, instrument self–adjustment and appropriate eyeglasses correction were used.
MCs levels, measured as Raman counts (SD), were 2425 (279), 2348 (195), 1928 (410) and 1921 (690) in the control, mild, medium and high myopia groups, respectively. The difference among the groups was statistically significant (p < 0.01). At the pairwise comparisons, the difference between the control and high myopia groups was also statistically significant (p < 0.05). Interestingly, a significant negative correlation was found between the MCs levels and the myopia grade (Spearman rho 0.50, p < 0.01).
A role for MCs in the pathogenesis and grade of myopia is proposed herein and future investigations are warranted to further clarify these aspects and to test their possible clinical use in the treatment of this pathology.
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