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M. Parravano, M. Centofanti, F. Oddone, D. Mineo, P. Borboni, A. Di Domenicantonio, R. Lauro, G. Manni; Role of Retinal Structural and Functional Testing in Type1 Diabetes Without Clinical Signs of Retinopathy . Invest. Ophthalmol. Vis. Sci. 2006;47(13):3873.
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to investigate the presence of retinal structural and functional impairment in patients with type1 diabetes without any fluorangiographic signs of retinopathy.
seventeen patients (M:F 8:9, age 36.53±8.9) with type 1 diabetes and 10 control subjects (M:F 2:8, age 26.4±3.86) have been included in the study. Inclusion criteria: age >18 years, clear lens, absence of any systemic active disease except diabetes. Exclusion criteria were: refractive error greater than ±6 diopters, any active or past ocular pathology or surgery, presence of any clinical or fluorangiographic signs of diabetic retinopathy. Patients performed a complete ophthalmological examination, fluorescein retinal angiography and haematologic tests including Hb1Ac . Functional tests included: Humphrey 30–2 SITA–Standard visual field (HFA), FDT–Matrix 30–2, and MP–1 microperimetry (macula 12°, 20 dB). Structural tests included: OCT–Stratus (Macular Thickness Map, RNFL Thickness 3.4) and GDx VCC. ANOVA–test and linear regression analysis were used to analyse data.
control subjects were significantly younger than diabetic patients (p=0.002). None of the 16 OCT parameters and none of the 5 GDx parameters considered showed significant differences among groups. Matrix and HFA mean deviation and pattern standard deviation were similar among groups. Retinal sensitivities measured by MP–1 were similar among diabetic and control subjects. No statistically significant correlation has been found between Hb1Ac levels and any retinal parameters (p<0.05).
Despite age differences, in this small cohort of patients, none of the functional and structural parameters considered in this study showed any statistical difference between young type–1 diabetic patients and controls.
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