May 2006
Volume 47, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2006
Detecting and Monitoring Progression of Visual Field Defects In Glaucoma Suspects with the mfVEP: A Longitudinal Study
Author Affiliations & Notes
  • V.C. Greenstein
    Columbia University, New York, NY
    Ophthalmology,
    Ophthalmology, NYU School of Medicine, New York, NY
  • X. Zhang
    Columbia University, New York, NY
    Psychology,
  • B. Wangsupadilok
    New York Eye and Ear Infirmary, New York, NY
  • R. Ritch
    New York Eye and Ear Infirmary, New York, NY
  • J. Liebmann
    Ophthalmology, NYU School of Medicine, New York, NY
    New York Eye and Ear Infirmary, New York, NY
  • T.M. Grippo
    New York Eye and Ear Infirmary, New York, NY
  • D.C. Hood
    Columbia University, New York, NY
    Psychology,
  • Footnotes
    Commercial Relationships  V.C. Greenstein, None; X. Zhang, None; B. Wangsupadilok, None; R. Ritch, None; J. Liebmann, None; T.M. Grippo, None; D.C. Hood, Zeiss, F; Pfizer, F.
  • Footnotes
    Support  NIH Grant EY02115
Investigative Ophthalmology & Visual Science May 2006, Vol.47, 4007. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      V.C. Greenstein, X. Zhang, B. Wangsupadilok, R. Ritch, J. Liebmann, T.M. Grippo, D.C. Hood; Detecting and Monitoring Progression of Visual Field Defects In Glaucoma Suspects with the mfVEP: A Longitudinal Study . Invest. Ophthalmol. Vis. Sci. 2006;47(13):4007.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: : To determine whether the multifocal visual evoked potential (mfVEP) can detect visual field defects and progression in glaucoma suspect (GLS) eyes with normal achromatic perimetry results.

Methods: : 69 GLS eyes of 39 patients were followed for 1–3 yrs. The criteria for GLS included vertical cup–disc ratio>=0.6, and/or disc asymmetry>=0.2, and/or a parapapillary nerve fiber layer defect, and/or focal disc notching, and/or disc hemorrhage. All eyes had normal achromatic perimetry, as defined by a PSD within 95% and a glaucoma hemifield test within normal limits on the Humphrey visual field 24–2 program. Monocular mfVEPs were obtained from each eye using a pattern–reversal dartboard array, 44.5 deg in diameter, and containing 60 sectors. Recording electrodes were placed at the inion (I) and I+4 cm, and also at two lateral locations up 1 cm and over 4 cm from I. Monocular and interocular analyses were performed [1,2]. For the mfVEP, a hemifield was defined as abnormal based on the following cluster test [3,4]: if 2 or more contiguous points had p<0.01, or 3 or more contiguous points had p<0.05 with at least one of these points with p<0.01. An eye was defined as abnormal if either one or both hemifields had a cluster of abnormal points. Progression was defined as an addition of a new cluster and/or expansion (more abnormal points) of an existing cluster.

Results: : Of the 69 GLS eyes, 14 eyes (20%) had abnormal mfVEPs on the first visit. On follow–up, 10 of these eyes retained their abnormal mfVEP hemifields with 4 showing progression, all had normal achromatic perimetry. Of the 55 eyes (80%) without a deficit, 49 (71%) remained stable and 6 (8%) developed clusters of abnormal points at follow–up.

Conclusions: : The mfVEP can detect field defects in GLS eyes that are not detected by achromatic automated perimetry. The mfVEP also detects progression of the deficits. Ref: 1.Hood et al (2002) Arch Ophthalmol. 2.Hood and Greenstein (2003) Prog Ret Eye Res. 3.Chauhan et al (1998) Doc Ophth 4. Goldberg et al (2002) Am J Opthalmol.

Keywords: electrophysiology: clinical • visual fields • perimetry 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×