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J.D. Sinclair, S.D. Anderson, C. Younger, C.K. Doyle, K.R. Woodward, M. Wall, R.H. Kardon; Correlation of Multifocal Visual Evoked Potential (MVEP) With OCT Retinal Nerve Fiber Layer (RNFL) in Glaucoma . Invest. Ophthalmol. Vis. Sci. 2006;47(13):4014.
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© ARVO (1962-2015); The Authors (2016-present)
To determine if suprathreshold measures of optic nerve function (measured by MVEP) correlate better with axon number (measured by retinal nerve fiber layer thickness) compared to threshold measures of visual function.
11 glaucoma eyes (POAG n=7, NTG n=3, juvenile OAG n=1) were tested 5 times within a 5 week period by MVEP (Accumap), threshold perimetry (HVF SITA standard 24–2), and optical coherence tomography (OCT) in one eye.
The most significant correlation was found between the average retinal nerve fiber layer thickness and the MVEP severity index (correlation R=0.832, p=0.001) compared to threshold perimetry, whether one session was analyzed or the average of 5 sessions was used.
A suprathreshold measure of optic nerve function (MVEP) showed a highly significant correlation with measures of retinal ganglion cell axon number in a relatively small group of glaucoma eyes and this correlation was greater compared to threshold measures of optic nerve function.
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