May 2006
Volume 47, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2006
Biologically Effective Cataractogenic Irradiance of Ultraviolet Radiation, Corrected for Spectral Irradiance of the Source, Age and Exposure Time
Author Affiliations & Notes
  • P.G. Soderberg
    Clinical neuroscience, Karolinska Inst/St. Erik, Stockholm, Sweden
    Ophthalmology, Mälarsjukhuset, Eskilstuna, Eskilstuna, Sweden
  • X. Dong
    Clinical neuroscience, Karolinska Inst/St. Erik, Stockholm, Sweden
  • S. Löfgren
    Clinical neuroscience, Karolinska Inst/St. Erik, Stockholm, Sweden
    Veterinary and Bomedical Sciences, University of Nebraska–Lincoln, Lincoln, NE
  • M. Ayala
    Clinical neuroscience, Karolinska Inst/St. Erik, Stockholm, Sweden
    Ophthalmology, Örebro University Hospital, Örebro, Sweden
  • L. Meyer
    Clinical neuroscience, Karolinska Inst/St. Erik, Stockholm, Sweden
    Ophthalmology, Bonn university, Bonn, Germany
  • V. Mody
    Clinical neuroscience, Karolinska Inst/St. Erik, Stockholm, Sweden
  • M. Kakar
    Clinical neuroscience, Karolinska Inst/St. Erik, Stockholm, Sweden
  • F. Zhang
    Clinical neuroscience, Karolinska Inst/St. Erik, Stockholm, Sweden
    Ophthalmology, University of Dalian, Dalian, China
  • Footnotes
    Commercial Relationships  P.G. Soderberg, None; X. Dong, None; S. Löfgren, None; M. Ayala, None; L. Meyer, None; V. Mody, None; M. Kakar, None; F. Zhang, None.
  • Footnotes
    Support  KI–funds, SRC grant K2004–74KX–15035–01A, SCWLSR 2002–0598
Investigative Ophthalmology & Visual Science May 2006, Vol.47, 4076. doi:
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      P.G. Soderberg, X. Dong, S. Löfgren, M. Ayala, L. Meyer, V. Mody, M. Kakar, F. Zhang; Biologically Effective Cataractogenic Irradiance of Ultraviolet Radiation, Corrected for Spectral Irradiance of the Source, Age and Exposure Time . Invest. Ophthalmol. Vis. Sci. 2006;47(13):4076.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To develop an algorithm for biologically effective cataractogenic irradiance of ultraviolet radiation corrected for spectral distribution of the source, age, and exposure time.

Methods: : In current safety standards for avoidance of cataract after an in vivo exposure to ultraviolet radiation (UVR), the biologically efficient irradiance is estimated based on qualitatively determined spectral sensitivity and the spectral irradiance of the source. Recently, quantitatively determined spectral sensitivity, dependence on age, and dependence on exposure time, was published. Based on those data, we developed an algorithm for determination of biologically effective cataractogenic irradiance corrected for spectral irradiance of the source, age of the exposed individual and the exposure time.

Results: : The algorithm demonstrates that the biologically effective cataractogenic irradiance depends strongly on spectral distribution of the source, strongly on the age of the exposed individual and to some extent on exposure time. The biologically effective cataractogenic irradiance for a particular source, for an individual of a specific age and for a particular exposure time can be used for estimation of the Safe Exposure Duration (SED).

Conclusions: : Safety standards for avoidance of UVR cataract should consider the spectral distribution of the source, the age of the individual exposed and the exposure time.

Keywords: cataract • radiation damage: light/UV • computational modeling 
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