May 2006
Volume 47, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2006
Cataract in Diabetes; The Reykjavik Eye Study
Author Affiliations & Notes
  • H. Sasaki
    Kanazawa Medical University, Uchinada, Japan
    Department of Ophthalmology,
    Division of Vision Research for Environmental Health, Institute of Kanazawa Medical University, Uchinada, Japan
  • K. Nagai
    Kanazawa Medical University, Uchinada, Japan
    Department of Ophthalmology,
  • M. Kojima
    Kanazawa Medical University, Uchinada, Japan
    Department of Ophthalmology,
    Division of Vision Research for Environmental Health, Institute of Kanazawa Medical University, Uchinada, Japan
  • Y. Sakamoto
    Kanazawa Medical University, Uchinada, Japan
    Department of Ophthalmology,
    Division of Vision Research for Environmental Health, Institute of Kanazawa Medical University, Uchinada, Japan
  • R. Honda
    Kanazawa Medical University, Uchinada, Japan
    Department of Social and Environmental Medicine,
  • F. Jonasson
    Department of Ophthalmology, University of Iceland, Reykjavik, Iceland
  • K. Sasaki
    Division of Vision Research for Environmental Health, Institute of Kanazawa Medical University, Uchinada, Japan
  • Footnotes
    Commercial Relationships  H. Sasaki, None; K. Nagai, None; M. Kojima, None; Y. Sakamoto, None; R. Honda, None; F. Jonasson, None; K. Sasaki, None.
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science May 2006, Vol.47, 4136. doi:
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    • Get Citation

      H. Sasaki, K. Nagai, M. Kojima, Y. Sakamoto, R. Honda, F. Jonasson, K. Sasaki; Cataract in Diabetes; The Reykjavik Eye Study . Invest. Ophthalmol. Vis. Sci. 2006;47(13):4136.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To examine cataract prevalence, five–year incidence and rate of surgical treatment in diabetic and non–diabetic participants of the Reykjavik Eye Study (RES).

Methods: : Of the 1045 subjects who participated in the RES in 1996, 846 (376 males and 470 females, Mean age 69.1±9.0 yrs old) or 88.2% of the 959 survivors were reexamined five years later in 2001. Classification of the three main types of opacity was determined from photographed images using the WHO classification system. Eyes which underwent cataract surgery prior to the first RES were excluded. A questionnaire collecting information regarding diabetes, age, gender, smoking, alcohol consumption, systemic steroid and cataract surgery during this five year follow–up period was administered. Data was analyzed using a logistic regression model.

Results: : We found 74 cases of diabetes (8.7%). In non–diabetics vs. diabetics, the percentages of cortical, nuclear and posterior subcapsular cataracts were 29.8 vs. 45.5%; 18.0 vs. 10.6% and 5.2 vs. 8.1%. Five year incidences were 16.2 vs. 33.9%; 9.0 vs. 6.3% and 4.3 vs. 7.7%. Five year cataract surgery rates were 5.3 vs. 8.1%. Subjects with diabetes showed higher cortical cataract prevalence (relative risk 1.63; 95% confidence interval 0.93–2.84; P=0.09) and significantly higher incidence (rr 2.30; 1.23–4.18; p<0.01). The incidence of nuclear cataract was significantly lower in the diabetes group (rr 0.32; 0.12–0.75; P=0.01). The incidences of posterior subcapsular cataract and cataract surgery were not significantly different between the groups.

Conclusions: : Diabetes patients in Iceland had increased risk of cortical cataract and lower risk of nuclear cataract progression. The increased risk of cortical cataract in diabetics concurs with findings of previous epidemiologic studies. Some aspect of diabetes may protect against nuclear cataract.

Keywords: cataract • diabetes • clinical (human) or epidemiologic studies: prevalence/incidence 
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