May 2006
Volume 47, Issue 13
ARVO Annual Meeting Abstract  |   May 2006
PEDFs Presence in Subretinal Fluid and its Possible Role in Wound Healing Following Retinal Detachment
Author Affiliations & Notes
  • O. Abdiu
    Dept, Karolinska, Stockholm, Sweden
  • G. Olivestedt
    Dept, Karolinska, Stockholm, Sweden
  • L. Berglin
    Dept, Karolinska, Stockholm, Sweden
  • G. Van Setten
    Dept, Karolinska, Stockholm, Sweden
  • Footnotes
    Commercial Relationships  O. Abdiu, None; G. Olivestedt, None; L. Berglin, None; G. Van Setten, None.
  • Footnotes
    Support  the Kronprinsessan Margaretas Committee for Impaired Vision, Stockholm, Sweden and The Foundation for the Promotion of Vision and Visual Science (Synfrämjandets Forskningsfond), Stockholm, Sweden.
Investigative Ophthalmology & Visual Science May 2006, Vol.47, 4228. doi:
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      O. Abdiu, G. Olivestedt, L. Berglin, G. Van Setten; PEDFs Presence in Subretinal Fluid and its Possible Role in Wound Healing Following Retinal Detachment . Invest. Ophthalmol. Vis. Sci. 2006;47(13):4228.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : PEDF (pigment epithelium derived factor) is a member of the serpin family of protease inhibitors. It is considered to be an important regulator of human eye disease and is known to inhibit angiogenesis. We have therefore investigated the presence of PEDF in the subretinal fluid (SRF) of patients with retinal detachment.

Methods: : Eighteen samples from SRF were collected from patients during retinal detachment surgery. Specific ELISA analysis was performed with specific IgG against human PEDF.

Results: : PEDF was detected in the subretinal fluid of all cases. The mean concentration of PEDF was 33.9 ng/ml (SD ng/ml; range 5.3 ng/ ml to 74.7 ng/ml). The majority of samples had however a concentration of more than 22 ng PEDF / ml fluid.

Conclusions: : PEDF appears to be a constant component of the fluid accumulating in the subretinal space after retinal detachment. The known effects of PEDF, however, suggest that it may be involved in physiological processes of wound healing in the subretinal space.

Keywords: retinal detachment • growth factors/growth factor receptors • wound healing 

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