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S.J. Bakri, J.S. Pulido, P. Mukherjee, R.J. Marler, D. Mukhopadhyay; Lack of Retinal Toxicity of Intravitreal Nanogold, a Novel Antiangiogenic and Long–Term Delivery Agent . Invest. Ophthalmol. Vis. Sci. 2006;47(13):4292.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the retinal toxicity of intravitreal nanogold, a novel antiangiogenic and long–term delivery agent.
One eye of each of 8 Dutch–belted rabbits was injected with intravitreal nanogold; the other eye served as a control. 4 rabbits received a dose of 67 um/0.1cc of nanogold intravitreally into one eye; and the other 4 rabbits were injected with 670 um/0.1cc of nanogold intravitreally into one eye. At one week, the rabbits were sacrificed and both eyes enucleated. The eyes were fixed with 2% paraformaldehyde and sectioned for histological examination.
In all injected and control eyes, there was mild vacuolization in the inner plexiform and ganglion cell layers. The retina and retinal pigment epithelium were otherwise histologically normal.
Intravitreal nanogold at concentrations of 67 um/0.1cc and 670 um/0.1cc showed no signs of retinal toxicity on histological examination.
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