May 2006
Volume 47, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2006
The Effect of Cfh Y402h Polymorphism on Recent Exudative AMD Lesion Parameters
Author Affiliations & Notes
  • I.J. Immonen
    Helsinki University Hospital, Helsinki, Finland
    Ophthalmology,
  • S. Seitsonen
    Helsinki University Hospital, Helsinki, Finland
    Ophthalmology,
  • J. Holopainen
    Helsinki University Hospital, Helsinki, Finland
    Ophthalmology,
  • I. Järvelä
    Helsinki University Hospital, Helsinki, Finland
    Molecular genetics,
  • P. Ranta, Sr.
    Helsinki University Hospital, Helsinki, Finland
    Ophthalmology,
  • P. Ranta, Sr.
    Helsinki University Hospital, Helsinki, Finland
  • 1A
    Helsinki University Hospital, Helsinki, Finland
    Ophthalmology,
  • P. Tommila
    Helsinki University Hospital, Helsinki, Finland
    Ophthalmology,
  • Footnotes
    Commercial Relationships  I.J. Immonen, None; S. Seitsonen, None; J. Holopainen, None; I. Järvelä, None; P. Ranta, None; P. Ranta, None; P. Tommila, None.
  • Footnotes
    Support  Sohlberg and Paulo foundations and research funds of the HUS
Investigative Ophthalmology & Visual Science May 2006, Vol.47, 4340. doi:
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      I.J. Immonen, S. Seitsonen, J. Holopainen, I. Järvelä, P. Ranta, Sr., P. Ranta, Sr., 1A, P. Tommila; The Effect of Cfh Y402h Polymorphism on Recent Exudative AMD Lesion Parameters . Invest. Ophthalmol. Vis. Sci. 2006;47(13):4340.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To evaluate the impact of CFH Y402H polymorphism on clinical parameters in recent exudative AMD lesions.

Methods: : We analyzed the clinical data and fluorescein angiograms of 165 unselected patients attending the retina clinic at our institution for recent exudative AMD.The presence and area of various lesion parameters were recorded from the digital (Topcon or Heidelberg) angiograms.

Results: : Mean lesion size (classic+occultcnv+serous PED, if present) was 11.0 mm2 in patients, homozygous for the CHF polymorphism (CC), 8.8 mm2 in heterozygous patients (CT) and 8.5 mm2 in those with the normal genotype (TT)(ns). The areas of classic and occult cnv together but without serous PED area were 8.7, 6.8 and 5.6 mm2, respectively(ns). There was a trend for the CC patients to have more frequently the minimally classic, and less frequently the predomintly classic lesion composition than the CT or TT subjects..

Conclusions: : We observed a trend for the lesions to be larger and more frequently minimally classic in patients homozygous for the CHF Y402H polymorphism, but the obsevations did not reach statistical significance.

Keywords: age-related macular degeneration • genetics 
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