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N. Bhatt, R. Bhojwani, A. Morrison, J. Kwartz, S. Shah; 10–Year Follow–Up of Ocular Hypertensive Patients Within the Bolton Corneal Thickness Study.Can Measured Factors Predict Prognostic Outcomes? . Invest. Ophthalmol. Vis. Sci. 2006;47(13):4426.
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This is a 10–year follow up of a cohort of patients examining the effects of central corneal thickness (CCT), presenting intraocular pressure (IOP), age and gender on the risk of progression of ocular hypertension (OHT) to primary glaucoma (POAG).
58 case notes from a cohort at the Bolton Royal Infirmary initially assessed 10 years ago were reviewed again. Presenting CCT, IOP, age and gender were recorded. Development of POAG was assessed by visual field and/or optic disc changes being present. The effects of the above variables were analysed in a multivariate logistic regression model following a preliminary univariate analysis.
50 out of 116 eyes developed primary open angle glaucoma over the 10–year period. Thinner CCT (odds ratio 0.985), higher presenting IOP (odds ratio 1.131) and increasing age (odds ratio 1.062) were found to be associated with progression to POAG.
Patients with a CCT of 579µm or more, a presenting intraocular pressure of 26mmHg or less and age 75 or less had a lower risk of developing POAG within this cohort of patients.
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