May 2006
Volume 47, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2006
Retinal Tolerance of Heavy Silicone Oil Using Perfluorobutylpentane Dependent of Viscosity and Density
J.A. Mackiewicz; W. Hiebl; H. Meinert; B. Muhling; K. Maaijwee; C. Luke; N. Kociok; Z. Zagórski; B. Kirchhof; A.M. Joussen
Author Affiliations & Notes
  • J.A. Mackiewicz
    Ophthalmology, Department of Vitreoretinal Surgery, University of Cologne, Germany
    Ophthalmology, Medical University, Lublin, Poland
  • W. Hiebl
    Fluoron GmbH, Neu–Ulm, Germany
  • H. Meinert
    Fluoron GmbH, Neu–Ulm, Germany
  • B. Muhling
    Fluoron GmbH, Neu–Ulm, Germany
  • K. Maaijwee
    Ophthalmology, Department of Vitreoretinal Surgery, University of Cologne, Germany
  • C. Luke
    Ophthalmology, Department of Vitreoretinal Surgery, University of Cologne, Germany
  • N. Kociok
    Ophthalmology, Department of Vitreoretinal Surgery, University of Cologne, Germany
  • Z. Zagórski
    Ophthalmology, Medical University, Lublin, Poland
  • B. Kirchhof
    Ophthalmology, Department of Vitreoretinal Surgery, University of Cologne, Germany
  • A.M. Joussen
    Ophthalmology, Department of Vitreoretinal Surgery, University of Cologne, Germany
  • Footnotes
    Commercial Relationships  J.A. Mackiewicz, None; W. Hiebl, Fluoron GmbH, E; H. Meinert, Fluoron GmbH, C; B. Muhling, Fluoron GmbH, C; K. Maaijwee, None; C. Luke, None; N. Kociok, None; Z. Zagórski, None; B. Kirchhof, None; A.M. Joussen, None.
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science May 2006, Vol.47, 4679. doi:
  • Views
  • Share
  • Tools
    • Alerts
      User Alerts
      You are adding an alert for:
      Retinal Tolerance of Heavy Silicone Oil Using Perfluorobutylpentane Dependent of Viscosity and Density
      You will receive an email whenever this article is corrected, updated, or cited in the literature. You can manage this and all other alerts in My Account
      The alert will be sent to:
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation
      Citation

      J.A. Mackiewicz, W. Hiebl, H. Meinert, B. Muhling, K. Maaijwee, C. Luke, N. Kociok, Z. Zagórski, B. Kirchhof, A.M. Joussen; Retinal Tolerance of Heavy Silicone Oil Using Perfluorobutylpentane Dependent of Viscosity and Density . Invest. Ophthalmol. Vis. Sci. 2006;47(13):4679.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

      ×
    • Get Permissions
  • Supplements
Abstract

Purpose: : Heavy silicone oils are currently under investigation as a permanent tamponade in eye with inferior PVR. Here, we investigated Densiron 68 ® and two new heavy silicone oils on the basis of perfluorobutylpentane (F4H5) of variable viscosity and density with respect to their long–term tolerability in a rabbit model

Methods: : After vitrectomy and fluid–air exchange, the left eye of each 5 rabbits in each group was filled with either HSO 1500 (Densiron 68 ®), Perfluorobutylpentane and HSO 3000 or HSO 5000 mPas viscosity. Densiron 68 ® (Fluoron GmbH, Germany) is a mixture of 30.5 weight–% F6H8 und 69.5 weight–% silicone oil 5000. Due to the higher solubility of F4H5 in comparison with F6H8, we used F4H5 to generate highly viscous heavy silicone oils. To create the high viscosity required, highly purified F4H5 was added to silicone oils (pharmaceutical grade) of 60,000 mPas and 100,000 mPas viscosity. In addition, we investigated the biocompatibility of pure F4H5 as tamponading agent. Siluron 1000 and 5000 (Fluoron GmbH, Germany) served as a control as well as silicone oil of 3000 mPas generated form a combination of both. Detailed clinical investigation, ERG testing and histological evaluation was performed throughout a 3 months follow–up.

Results: : All heavy silicone oils tested (Densiron 68 ®, HSO 3000 und 5000) as well as the three controls (silicone oil of 1000, 3000, and 5000 mPas) were well tolerated over 3 months in a rabbit model. There was no emulsification nor inflammatory reaction or cataract formation in either of the heavy silicone oils or the controls. ERG–testing demonstrated no functional alterations. Histologically, the retina was unaffected. If pure F4H5 was investigated, in 50% of the eyes some emulsification but no inflammatory reaction nor histological damage was observed within three months.

Conclusions: : All silicone oils and the heavy silicone oils tested as well as pure F4H5 were biocompatible in long–term tamponade in the rabbit eye. Heavy silicone oils on the basis of F4H5 combine the advantages of an inferior permanent tamponade with an adjustable higher density.

Keywords: vitreoretinal surgery • vitreous substitutes 
© 2006, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×
This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy.Accept