May 2006
Volume 47, Issue 13
ARVO Annual Meeting Abstract  |   May 2006
Polysomnographic Findings In Stable And Progressive Glaucoma
Author Affiliations & Notes
  • P.O. Lundmark
    University of Toronto, Toronto, ON, Canada
    Ophthalmology and Vision Sciences,
    Optometry and Visual Science, Buskerud University College, Kongsberg, Norway
  • G.E. Trope
    University of Toronto, Toronto, ON, Canada
    Ophthalmology and Vision Sciences,
  • C.M. Shapiro
    University of Toronto, Toronto, ON, Canada
  • J.G. Flanagan
    University of Toronto, Toronto, ON, Canada
    Ophthalmology and Vision Sciences,
    School of Optometry, University of Waterloo, Waterloo, ON, Canada
  • Footnotes
    Commercial Relationships  P.O. Lundmark, None; G.E. Trope, None; C.M. Shapiro, None; J.G. Flanagan, None.
  • Footnotes
    Support  The Glaucoma Research Society of Canada
Investigative Ophthalmology & Visual Science May 2006, Vol.47, 4784. doi:
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      P.O. Lundmark, G.E. Trope, C.M. Shapiro, J.G. Flanagan; Polysomnographic Findings In Stable And Progressive Glaucoma . Invest. Ophthalmol. Vis. Sci. 2006;47(13):4784.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : To investigate the difference in objective measures of sleep between patients with stable and progressive glaucoma.

Methods: : Twenty–nine consecutive patients with primary open angle glaucoma (POAG) or normal tension glaucoma (NTG) were recruited from a tertiary care hospital clinic in Toronto, Canada. They were between 50 and 70 yrs and had been followed for at least 3 years. Patients were classified as stable (n = 17, f/m: 6/11) or progressive (n = 12, f/m: 6/6) based on their VFs and/or presence of disk hemorrhage(s). In addition, 11 controls (f/m: 6/5) in the same age range were recruited by advertising for volunteers within the hospital. Global exclusion criteria were major health and / or sleep problems and the use of drugs known to affect sleep. Full overnight polysomnography (PSG) was performed during 2 standardized nights (11 pm – 6 am) in a dedicated hospital sleep laboratory. The PSG of the second night was analyzed. Outcome measures were compared within gender specific groups.

Results: : Females with progressive glaucoma tended to have more deep sleep (stage 3 & 4) than stable cases and normal controls (19.2 % vs. 14.4 % vs. 12.5 %, p = 0.116). The proportion of females with deep sleep in the upper 50th percentile was greater in progressive cases than in stable cases (83.3 % vs. 16.7 %, p = 0.041). Males did not differ between the groups, except for a trend towards more light sleep in stable males than in controls and progressive cases (55.9 % vs. 47.2 % vs. 47.4 %, p = 0.169). Measures of respiratory disturbance were similar among comparison groups in both genders. Slow wave sleep was pronounced in all patients with progressive NTG.

Conclusions: : Results indicate for the first time that deep sleep may represent a risk factor in progressive glaucoma, and that this effect may be specific for women. Further research combining overnight polysomnography with blood pressure monitoring is warranted.

Keywords: circadian rhythms 

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