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M. Suzuki, S. Tanimoto, H. Okumichi, T. Ue, H. Tamura, H.K. Mishima, T. Kanamoto; The Association Of Cullin–5 With Retinal Cell Death . Invest. Ophthalmol. Vis. Sci. 2006;47(13):4814.
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In previous reports, the results of proteomics analysis of DBA2/J mouse, glaucoma model mouse, retina showed that the endogeneous protein expressions of Cullin–5 were up–regulated in nine months age. So, we intend to investigate the molecular and biological function of Cullin–5 on retinal ganglion cells (RGCs).
Immunohistochemistry procedure was performed in C57BL mice retina to examine the localization of Cullin–5. RNA knock down of Cullin–5 was also performed on retinal cells with or without glutamate treatment, and analyzed the cell biological changes.
Endogeneous Cullin–5 were specifically expressed RGCs. Retinal cell death induced by glutamate was inhibited by RNA knock down of Cullin–5.
Cullin–5 may play an important role on RGC death in glaucoma.
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