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J. Park, J.W. Jeoung, W.R. Wee, J.H. Lee, M.K. Kim, J.L. Lee; Clinical Efficacy of Amniotic Membrane Transplantation in the Treatment of Various Ocular Surface Diseases . Invest. Ophthalmol. Vis. Sci. 2006;47(13):4962.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate the efficacy of amniotic membrane transplantation(AMT) as a permanent patch graft in the treatment of various ocular surface diseases.
The medical records of the 63 patients who had undergone AMT permanently were retrospectively reviewed. The amniotic patches were grafted for the treatment of neurotrophic ulcers (n=15), inflammatory corneal ulcers (n=16), inflammatory or non–inflammatory scleral ulcers (n=11), painful bullous keratopathy even with any medication or therapeutic lens wear (n=8) and pterygium as an adjuvant with conjunctival autograft to inhibit recurrence (n=13). The overall success rate, the interval to epithelization, pain–subsiding time, mean frequencies of the transplantation, and complication were evaluated.
Mean follow–up was 10.7 months. The success rate in the patients with neurotrophic ulcer, inflammatory corneal ulcer, scleral ulcer and bullous keratopathy were 93.3%, 66.7%, 92.9% and 100% respectively. Conjunctival autograft with AMT showed 100% of success without recurrence during follow–up. AMT was repeated 4.1±2.3 times in 80% of inflammatory ulcers to achieve successful epithelialization. Each time to re–epithelization was 24.4±24.2, 20.4±5.8, and 16.9±7.0 days in patients with neurotrophic, inflammatory and scleral ulcers, respectively(p=0.431, independent t test). Pain–subsiding time was 25.8±19.9 days in intolerable bullous keratopathy. One case of infection was developed after AMT.
AMT showed high success with low complication in the treatment of neurotrophic, scleral ulcer, bullous keratopathy and pterygium, presenting partial success in the treatment of inflammatory corneal ulcers.
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