Long–Term Results of Mitomycin–C (mmc)–Aided Papillary Resection in Patients With Severe Ocular Allergies

Abstract

Purpose: : To investigate the long–term outcomes of MMC–aided papillary resection in patients with severe ocular allergies.

Methods: : Subjects were cases of atopic keratoconjunctivitis (AKC) and vernal keratoconjunctivitis (VKC) with corneal lesions refractory to conventional treatments. Mitomycin–aided papillary resection with 0.02% (7 eyes) or 0.05% (28 eyes) was performed in these patients. Recurrence of corneal lesions were compared between the two concentrations of MMC. The follow up period was from 2 years to 5 years postoperatively.

Results: : Corneal lesions swiftly healed in both groups. Short term recurrence (within 6 months) was inhibited in both groups. However, exacerbations within 2 years were less in the 0.05% group compared to the 0.02% group (32.1%, 71.4% respectively). No complications related to MMC use were observed in either group.

Conclusions: : Both 0.02% and 0.05% MMC–aided papillary resection were found to be effective in the treatment of severe ocular allergies complicated by corneal lesions. However, 0.05%MMC was more effective in preventing long–term exacerbations.

Keywords: conjunctivitis • inflammation • clinical (human) or epidemiologic studies: outcomes/complications