May 2006
Volume 47, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2006
Effect of Patanol on Tear Film Stability Stability
Author Affiliations & Notes
  • D. Welch
    ORA Clinical Research and Development, North Andover, MA
  • J.A. Davis
    ORA Clinical Research and Development, North Andover, MA
  • G. Torkildsen
    ORA Clinical Research and Development, North Andover, MA
  • G.W. Ousler, III
    ORA Clinical Research and Development, North Andover, MA
  • M.B. Abelson
    ORA Clinical Research and Development, North Andover, MA
    Harvard Medical School and Schepens Eye Research Institute, Boston, MA
  • Footnotes
    Commercial Relationships  D. Welch, None; J.A. Davis, None; G. Torkildsen, None; G.W. Ousler, None; M.B. Abelson, None.
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science May 2006, Vol.47, 4999. doi:https://doi.org/
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      D. Welch, J.A. Davis, G. Torkildsen, G.W. Ousler, III, M.B. Abelson; Effect of Patanol on Tear Film Stability Stability . Invest. Ophthalmol. Vis. Sci. 2006;47(13):4999. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

The purpose of this study was to evaluate the effect of Patanol® on tear film stability in normals.

 
Methods:
 

Eleven normal subjects underwent baseline examinations including tear film break–up time (TFBUT). Subjects received bilateral treatment with either Patanol® or Tears Naturale® II. TFBUT was then measured 5, 10 and 15 minutes after drop instillation. Twenty–four hours later subjects were crossed–over to receive bilateral treatment with the remaining study medication. All study procedures conducted at baseline were repeated.

 
Results:
 

The following table shows mean TFBUT in eyes treated with Patanol® versus Tears Naturale® II. No statistically significant differences in TFBUT were observed at any time point after drop instillation.  

 
Conclusions:
 

The data indicates that in normal subjects Patanol® has a similar effect to artificial tears on tear film stability, suggesting that Patanol® does not have a drying effect on the ocular surface.

 
Keywords: cornea: tears/tear film/dry eye • cornea: clinical science • clinical (human) or epidemiologic studies: treatment/prevention assessment/controlled clinical trials 
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