May 2006
Volume 47, Issue 13
ARVO Annual Meeting Abstract  |   May 2006
Ocular Manifestation At The Time Of Diagnosis In Japanese Patients With Untreated Grave's Disease
Author Affiliations & Notes
  • A. Kozaki
    Ophthalmology, Olympia, Tokyo, Japan
  • E. Taji
    Ophthalmology, Olympia, Tokyo, Japan
  • R. Inoue
    Ophthalmology, Olympia, Tokyo, Japan
  • T. Maeda
    Ophthalmology, Olympia, Tokyo, Japan
  • T. Inoue
    Ophthalmology, Olympia, Tokyo, Japan
  • Y. Inoue
    Ophthalmology, Olympia, Tokyo, Japan
  • H. Yoshimura
    Ito Hospital, Tokyo, Japan
  • K. Ito
    Ito Hospital, Tokyo, Japan
  • Footnotes
    Commercial Relationships  A. Kozaki, None; E. Taji, None; R. Inoue, None; T. Maeda, None; T. Inoue, None; Y. Inoue, None; H. Yoshimura, None; K. Ito, None.
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science May 2006, Vol.47, 5072. doi:
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      A. Kozaki, E. Taji, R. Inoue, T. Maeda, T. Inoue, Y. Inoue, H. Yoshimura, K. Ito; Ocular Manifestation At The Time Of Diagnosis In Japanese Patients With Untreated Grave's Disease . Invest. Ophthalmol. Vis. Sci. 2006;47(13):5072.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : To evaluate the ocular manifestation at early stage of Graves' Ophthalmopathy which is usually observed in the advance stage of ophthalmopathy in order to manage or treat ophthalmologically.

Methods: : One hundred eighty two patients; male 27, female 155; average age 37.6 years old ( range 12 ∼ 79 ) were employed. These patients were consecutively examined at eye hospital in collaboration of endocrinological hospital ( Ito ). All patients haven't been treated endocrinologically. Ophthalmic examination and MRI were implemented in all patients.

Results: : Fifty five percent of patients took the precedence of physical symptom, 17% of cases took the precedence of ocular manifestation. Exophthalmos reading 15.3±3.0 mm. Height of palpebral fissure 8.8±1.2 mm, prevalence of Dalrymple sign 51.6%, Graefe sign 48.9%, eyelid swelling 35.1%, swelling of lacrimal gland 19.8%, enlargement of extra ocular muscle 9.3%, disturbance of eye movement 4.4%, no case of optic nerve involvement. These ocular involvements were compared to previous report ( Kozaki et al ; 2004 ARVO 2717 ).

Conclusions: : Ocular involvement was observed in about 50 % of patients with Graves' disease. It was considered that the onset of ophthalmopathy may be immediate at the time of diagnosis of Graves' disease.

Keywords: orbit • clinical (human) or epidemiologic studies: natural history 

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