Abstract
Purpose: :
To evaluate the ocular manifestation at early stage of Graves' Ophthalmopathy which is usually observed in the advance stage of ophthalmopathy in order to manage or treat ophthalmologically.
Methods: :
One hundred eighty two patients; male 27, female 155; average age 37.6 years old ( range 12 ∼ 79 ) were employed. These patients were consecutively examined at eye hospital in collaboration of endocrinological hospital ( Ito ). All patients haven't been treated endocrinologically. Ophthalmic examination and MRI were implemented in all patients.
Results: :
Fifty five percent of patients took the precedence of physical symptom, 17% of cases took the precedence of ocular manifestation. Exophthalmos reading 15.3±3.0 mm. Height of palpebral fissure 8.8±1.2 mm, prevalence of Dalrymple sign 51.6%, Graefe sign 48.9%, eyelid swelling 35.1%, swelling of lacrimal gland 19.8%, enlargement of extra ocular muscle 9.3%, disturbance of eye movement 4.4%, no case of optic nerve involvement. These ocular involvements were compared to previous report ( Kozaki et al ; 2004 ARVO 2717 ).
Conclusions: :
Ocular involvement was observed in about 50 % of patients with Graves' disease. It was considered that the onset of ophthalmopathy may be immediate at the time of diagnosis of Graves' disease.
Keywords: orbit • clinical (human) or epidemiologic studies: natural history