May 2006
Volume 47, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2006
Fast Response? – Optical Coherence Tomography in Neovascular Age Related Macular Degeneration After Intravitreal Bevacicumab Injection
Author Affiliations & Notes
  • M. Volker
    Ophthalmology I, Univ. Augenklinik, Tubingen, Germany
  • Tuebingen Bevacizumab Study Group
    Ophthalmology I, Univ. Augenklinik, Tubingen, Germany
  • Footnotes
    Commercial Relationships  M. Volker, None.
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science May 2006, Vol.47, 5246. doi:
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      M. Volker, Tuebingen Bevacizumab Study Group; Fast Response? – Optical Coherence Tomography in Neovascular Age Related Macular Degeneration After Intravitreal Bevacicumab Injection . Invest. Ophthalmol. Vis. Sci. 2006;47(13):5246.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To investigate the therapeutic properties of bevacicumab (Avastin®) for treatment of neovascular age related macular degeneration within the first 24 to 48 hours after injection.

Methods: : In this open labeled, uncontrolled clinical study 42 eyes of 42 patients with neovascular age related macular degeneration were enrolled. Each eye received an intravitreal injection of 1.0 mg bevacicumab (Avastin®) under sterile conditions via pars plana. Optical coherence tomography (OCT) was performed at baseline and 24 to 48 hours for documentation of changes in retinal morphology and measurement of retinal thickness.

Results: : Reduction of edema and / or retinal thickness was seen in 85.7 Percent, pigment epithelium detachment decreased in 16.8 Percent. Significant changes in retinal morphology were seen in all patients.

Conclusions: : Our results indicate the effectiveness of intravitreal injection of bevacicumab (Avastin®) in patients with neovascular AMD for fast reduction of cystic formations in retinal morphology. Further studies will determine long term efficacy and safety.

Keywords: age-related macular degeneration • retinal neovascularization • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) 
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