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D. Lepore, M.M. Pagliara, A. Baldascino, R. De Santis, G. D'Amico, C. Angora, M. Laguardia, L. Orazi, F. Molle, E. Balestrazzi; How ET–ROP Study Modify ROP Treatment . Invest. Ophthalmol. Vis. Sci. 2006;47(13):5309.
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© ARVO (1962-2015); The Authors (2016-present)
To verify the impact of ETROP study on ROP management.
we analyse data on 703 inborn preterm screened for ROP between Jan 95 to Jun 05 in the NICU at the Catholic University Hospital in Rome. Inclusion criteria were: gestational age (GA) ≤32weeks and/or a birth weight (BW) ≤1500grams, plus all preterm judged at risk. The mean BW was 1254gr. (range 350–3560) and the mean GA was 29.6weeks (range 23–35wks). ROP was diagnosed in 243 cases (35% of all preterm) with a mean BW of 909.6gr and a mean GA of 27.7wks. We retrospectively analysed data record of all preterm that reached prethreshold, as defined by Cryo–ROP and verify their progression to threshold or regression. Starting from Jan 04 we applied ETROP criteria and therefore treat all type 1 pre–threshold ROP. We also verify the improvement of early treatment
from Jan 95 to Jun 05 prethreshold ROP was diagnosed in 98 preterms (195eyes; 13.9% of all preterm; mean GA 26.7wks, mean BW 803.3gr). According to ETROP Study 33 eyes were classified as type 1 prethreshold ( mean BW 663.9gr; mean GA 25.9wks) and 65 eyes type 2 (mean BW 877.2gr; mean GA 27.1wks).Ten eyes were ZI,St3+; 6 eyes ZI,St1 no+; 8 eyes ZI,St1–2+; 2 eyes ZI,St1–2 no+; 59 ZII,St3+;110 eyes ZII,St3 no+; 0 eyes ZII,St2+. 83eyes (42.3% of all prethreshold) underwent treatment. Favourable and good outcomes (as defined by Cryo–ROP) were achieved in 39 eyes (47.0%). From Jan 04 we applied ETROP study indication and treated 22 eyes type1 prethreshold ROP and 8 eyes type 2 progressed to "classical" threshold; favourable and good outcome were achieved in 18 eyes (60%). Using Cryo–ROP threshold from Jan 95 to Dec 03 we treated 55 eyes; unfavourable outcome was observed in 34 eyes (22 type 1 and 12 type 2 prethreshold).
the application of ETROP criteria deeply modified ROP treatments with an improvement of favourable and good outcome from 38.18% (pre ETROP) to 64.28% (post ETROP). The price that we paid is probably represented by the 14 eyes with type 1 prethreshold that spontaneously regressed before the adoption of ETROP criteria for treatment.
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