May 2006
Volume 47, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2006
How ET–ROP Study Modify ROP Treatment
Author Affiliations & Notes
  • D. Lepore
    Ophthalmology, Catholic University, Rome, Italy
  • M.M. Pagliara
    Ophthalmology, Catholic University, Rome, Italy
  • A. Baldascino
    Ophthalmology, Catholic University, Rome, Italy
  • R. De Santis
    Ophthalmology, Catholic University, Rome, Italy
  • G. D'Amico
    Ophthalmology, Catholic University, Rome, Italy
  • C. Angora
    Ophthalmology, Catholic University, Rome, Italy
  • M. Laguardia
    Ophthalmology, Catholic University, Rome, Italy
  • L. Orazi
    Ophthalmology, Catholic University, Rome, Italy
  • F. Molle
    Ophthalmology, Catholic University, Rome, Italy
  • E. Balestrazzi
    Ophthalmology, Catholic University, Rome, Italy
  • Footnotes
    Commercial Relationships  D. Lepore, None; M.M. Pagliara, None; A. Baldascino, None; R. De Santis, None; G. D'Amico, None; C. Angora, None; M. Laguardia, None; L. Orazi, None; F. Molle, None; E. Balestrazzi, None.
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science May 2006, Vol.47, 5309. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      D. Lepore, M.M. Pagliara, A. Baldascino, R. De Santis, G. D'Amico, C. Angora, M. Laguardia, L. Orazi, F. Molle, E. Balestrazzi; How ET–ROP Study Modify ROP Treatment . Invest. Ophthalmol. Vis. Sci. 2006;47(13):5309.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: : To verify the impact of ETROP study on ROP management.

Methods: : we analyse data on 703 inborn preterm screened for ROP between Jan 95 to Jun 05 in the NICU at the Catholic University Hospital in Rome. Inclusion criteria were: gestational age (GA) ≤32weeks and/or a birth weight (BW) ≤1500grams, plus all preterm judged at risk. The mean BW was 1254gr. (range 350–3560) and the mean GA was 29.6weeks (range 23–35wks). ROP was diagnosed in 243 cases (35% of all preterm) with a mean BW of 909.6gr and a mean GA of 27.7wks. We retrospectively analysed data record of all preterm that reached prethreshold, as defined by Cryo–ROP and verify their progression to threshold or regression. Starting from Jan 04 we applied ETROP criteria and therefore treat all type 1 pre–threshold ROP. We also verify the improvement of early treatment

Results: : from Jan 95 to Jun 05 prethreshold ROP was diagnosed in 98 preterms (195eyes; 13.9% of all preterm; mean GA 26.7wks, mean BW 803.3gr). According to ETROP Study 33 eyes were classified as type 1 prethreshold ( mean BW 663.9gr; mean GA 25.9wks) and 65 eyes type 2 (mean BW 877.2gr; mean GA 27.1wks).Ten eyes were ZI,St3+; 6 eyes ZI,St1 no+; 8 eyes ZI,St1–2+; 2 eyes ZI,St1–2 no+; 59 ZII,St3+;110 eyes ZII,St3 no+; 0 eyes ZII,St2+. 83eyes (42.3% of all prethreshold) underwent treatment. Favourable and good outcomes (as defined by Cryo–ROP) were achieved in 39 eyes (47.0%). From Jan 04 we applied ETROP study indication and treated 22 eyes type1 prethreshold ROP and 8 eyes type 2 progressed to "classical" threshold; favourable and good outcome were achieved in 18 eyes (60%). Using Cryo–ROP threshold from Jan 95 to Dec 03 we treated 55 eyes; unfavourable outcome was observed in 34 eyes (22 type 1 and 12 type 2 prethreshold).

Conclusions: : the application of ETROP criteria deeply modified ROP treatments with an improvement of favourable and good outcome from 38.18% (pre ETROP) to 64.28% (post ETROP). The price that we paid is probably represented by the 14 eyes with type 1 prethreshold that spontaneously regressed before the adoption of ETROP criteria for treatment.

Keywords: retinopathy of prematurity 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×